[5-cyano-2-(4-methoxy-phenyl)-2-thioxo-1-thia-3-aza-2λ⁵-phospha-spiro[5.5]undec-3-en-4-ylsulfanyl]-acetic acid ethyl ester

Base Information

• Chemical Name: [5-cyano-2-(4-methoxy-phenyl)-2-thioxo-1-thia-3-aza-2λ⁵-phospha-spiro[5.5]undec-3-en-4-ylsulfanyl]-acetic acid ethyl ester
• CAS No.: 668483-93-0
• Molecular Formula: C₂₀H₂₅N₂O₃PS₃
• Molecular Weight: 468.602

Synonyms:[5-cyano-2-(4-methoxy-phenyl)-2-thioxo-1-thia-3-aza-2λ⁵-phospha-spiro[5.5]undec-3-en-4-ylsulfanyl]-acetic acid ethyl ester

Chemical Property of [5-cyano-2-(4-methoxy-phenyl)-2-thioxo-1-thia-3-aza-2λ⁵-phospha-spiro[5.5]undec-3-en-4-ylsulfanyl]-acetic acid ethyl ester

Chemical Property:

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Technology Process of [5-cyano-2-(4-methoxy-phenyl)-2-thioxo-1-thia-3-aza-2λ⁵-phospha-spiro[5.5]undec-3-en-4-ylsulfanyl]-acetic acid ethyl ester

There total 3 articles about [5-cyano-2-(4-methoxy-phenyl)-2-thioxo-1-thia-3-aza-2λ⁵-phospha-spiro[5.5]undec-3-en-4-ylsulfanyl]-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

chloroacetic acid ethyl ester (105-39-5) + 5'-cyano-2'-(4-methoxyphenyl)spiro[cyclohexane-1,6'-perhydro[1,3,2]thiazaphosphixane]-2',4'-disulfide (668483-59-8) → [5-cyano-2-(4-methoxy-phenyl)-2-thioxo-1-thia-3-aza-2λ5-phospha-spiro[5.5]undec-3-en-4-ylsulfanyl]-acetic acid ethyl ester (668483-93-0)

Guidance literature:

With sodium acetate; In ethanol; for 2h; Heating;

DOI:10.1080/10426500307871

Reference yield:

Lawessons reagent (19172-47-5,94367-93-8) → [5-cyano-2-(4-methoxy-phenyl)-2-thioxo-1-thia-3-aza-2λ5-phospha-spiro[5.5]undec-3-en-4-ylsulfanyl]-acetic acid ethyl ester (668483-93-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 63 percent / acetonitrile / 7 h / Heating

2: 89 percent / CH₃COONa / ethanol / 2 h / Heating

With sodium acetate; In ethanol; acetonitrile;

DOI:10.1080/10426500307871

Reference yield:

2-cyano-2-cyclohexylidenethioacetamide (129224-53-9) → [5-cyano-2-(4-methoxy-phenyl)-2-thioxo-1-thia-3-aza-2λ5-phospha-spiro[5.5]undec-3-en-4-ylsulfanyl]-acetic acid ethyl ester (668483-93-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 63 percent / acetonitrile / 7 h / Heating

2: 89 percent / CH₃COONa / ethanol / 2 h / Heating

With sodium acetate; In ethanol; acetonitrile;

DOI:10.1080/10426500307871

upstream raw materials:

chloroacetic acid ethyl ester

5'-cyano-2'-(4-methoxyphenyl)spiro[cyclohexane-1,6'-perhydro[1,3,2]thiazaphosphixane]-2',4'-disulfide

Lawessons reagent

2-cyano-2-cyclohexylidenethioacetamide

Downstream raw materials:

C₂₂H₂₇N₂O₃PS₅

C₁₉H₂₁N₄O₂PS₄

C₂₀H₂₅N₂O₃PS₃

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