129224-53-9

Upstream product

• 7357-70-2 Cyanothioacetamide 
• 108-94-1 cyclohexanone 

Downstream Products

• 129340-04-1 3-Thioxo-1-p-tolyl-2,3,5,6,7,8-hexahydro-isoquinoline-4-carbonitrile 
• 129339-97-5 2-amino-4-p-tolyl-5,6,7,8-tetrahydro-4H-napathalene-1,3,3-tricarbonitrile 
• 500592-88-1 1-pyridin-3-yl-3-thioxo-2,3,5,6,7,8-hexahydro-isoquinoline-4-carbonitrile 
• 1421005-86-8 3-[2-(3,4-dihydroxyphenyl)-2-oxoethylsulfanyl]-1-isopropyl-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile 
• 332174-94-4 benzyl 2-(4-cyano-1-phenyl-5,6,7,8-tetrahydroisoquinolin-3-ylsulfanyl)acetate 
• 1421005-88-0 3-[2-(3,4-dihydroxyphenyl)-2-oxoethylsulfanyl]-1-phenyl-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile 
• 303786-36-9 (1-amino-5-phenyl-6,7,8,9-tetrahydrothieno[2,3-c]isoquinolin-2-yl)(phenyl)methanone 
• 1421005-76-6 3-(2-cyanoethylsulfanyl)-1-phenyl-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile 
• 1421005-78-8 2-[2-(4-cyano-1-methyl-5,6,7,8-tetrahydroisoquinolin-3-ylsulfanyl)-1-phenylethylidene]malononitrile 
• 94833-28-0 1-phenyl-3-thioxo-2,3,5,6,7,8-hexahydroisoquinoline-4-carbonitrile 
• 339153-97-8 1-(4-bromophenyl)-3-thioxo-2,3,5,6,7,8-hexahydroisoquinoline-4-carbonitrile 
• 77198-43-7 2-amino-4-(4-methoxyphenyl)-4a,5,6,7-tetrahydronaphthalene-1,3,3(4H)-tricarbonitrile 
• 77198-61-9 2-amino-4-(4-methoxyphenyl)-5,6,7,8-tetrahydronaphthalene-1,3-dicarbonitrile 

Relevant academic research and scientific papers

Regioselective reduction of 2-cyanoprop-2-enethioamides with sodium borohydride

Treatment of 2-cyanoprop-2-enethioamides with NaBH4 in EtOH gave C-alkylated cyanothioacetamides in 62-69% yields.

The Radziszewski oxidation of cycloalkylidene-α-(thiazol- 2-yl)acetonitriles: A new approach toward spirooxiranes

Upon treatment with H2O2/KOH in EtOH or with Na 2CO3/H2O2 in acetone, cycloalkylidene-α-(4-arylthiazol-2-yl)acetonitriles afforded 2-(4-arylthiazol-2-yl)-1-oxaspiro[2.5]octane-2-carboxamides and 2-(4-arylthiazol-2-yl)-1-oxaspiro[2.4]heptane-2-carboxamides in excellent yields (76-100%).

Unexpected Products of the Reaction of Cycloalkylidene(cyano)thioacetamides with Arylmethylenemalononitriles: a Different Novel Synthetic Route to Condensed Pyridine-2(1H)-thiones and Condensed Carbocyclic Nitriles

A novel synthesis of condensed 3-cyanopyridine-2(1H)-thiones and condensed carbocyclic nitrile derivatives utilizing arylmethylene(cyano)thioacetamides and cycloalkylidenemalononitriles or arylmethylenemalononitriles and cycloalkylidene(cyano)thioacetamides as starting components is described.