2-(3',4'-Dimethoxy-β-phenethyl)-6,7-dimethoxy-1,2,3,4-tetrahydro-3-isoquinolone

Base Information

• Chemical Name: 2-(3',4'-Dimethoxy-β-phenethyl)-6,7-dimethoxy-1,2,3,4-tetrahydro-3-isoquinolone
• CAS No.: 75938-11-3
• Molecular Formula: C₂₁H₂₅NO₅
• Molecular Weight: 371.433
• Mol file: 75938-11-3.mol

Synonyms:2-(3',4'-Dimethoxy-β-phenethyl)-6,7-dimethoxy-1,2,3,4-tetrahydro-3-isoquinolone

Chemical Property of 2-(3',4'-Dimethoxy-β-phenethyl)-6,7-dimethoxy-1,2,3,4-tetrahydro-3-isoquinolone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3',4'-Dimethoxy-β-phenethyl)-6,7-dimethoxy-1,2,3,4-tetrahydro-3-isoquinolone

There total 5 articles about 2-(3',4'-Dimethoxy-β-phenethyl)-6,7-dimethoxy-1,2,3,4-tetrahydro-3-isoquinolone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.1%

ethyl 2-(bromomethyl)-4,5-dimethoxyphenylacetate (73053-80-2) + 2-(3,4-dimethoxyphenyl)-ethylamine (120-20-7) → 2-(3',4'-Dimethoxy-β-phenethyl)-6,7-dimethoxy-1,2,3,4-tetrahydro-3-isoquinolone (75938-11-3)

Guidance literature:

With potassium carbonate; potassium iodide; In 1,4-dioxane; for 72h; Heating;

Reference yield: 56.3%

3,4-dimethoxyphenethyl bromide (40173-90-8) + 6,7-Dimethoxy-1,4-dihydro-2H-isoquinoline-3-one (21763-07-5) → 2-(3',4'-Dimethoxy-β-phenethyl)-6,7-dimethoxy-1,2,3,4-tetrahydro-3-isoquinolone (75938-11-3)

Guidance literature:

With potassium carbonate; potassium iodide; In ethanol; at 100 ℃; for 24h;

Reference yield:

6,7-dimethoxy-3,4-dihydro-1H-2-benzopyran-3-one (16135-41-4) → 2-(3',4'-Dimethoxy-β-phenethyl)-6,7-dimethoxy-1,2,3,4-tetrahydro-3-isoquinolone (75938-11-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / HBr / ethanol / 24 h / Ambient temperature

2: 81.1 percent / K₂CO₃/KI / dioxane / 72 h / Heating

With hydrogen bromide; potassium carbonate; potassium iodide; In 1,4-dioxane; ethanol;

upstream raw materials:

3,4-dimethoxyphenethyl bromide

6,7-Dimethoxy-1,4-dihydro-2H-isoquinoline-3-one

ethyl 2-(bromomethyl)-4,5-dimethoxyphenylacetate

2-(3,4-dimethoxyphenyl)-ethylamine

Downstream raw materials:

2,3,10,11-tetramethoxy-5,6,7,8,13,13a-hexahydroisoquinolino[3,2-a]isoquinoline

N-(3,4-dimethoxy-β-phenethyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline