5-aminocarbonyl-2-chloro-N₄-(1,2,2,6,6-pentamethylpiperidin-4-yl)-4-pyrimidineamine hydrochloride

Base Information

• Chemical Name: 5-aminocarbonyl-2-chloro-N₄-(1,2,2,6,6-pentamethylpiperidin-4-yl)-4-pyrimidineamine hydrochloride
• CAS No.: 1309831-09-1
• Molecular Formula: C₁₅H₂₄ClN₅O*ClH
• Molecular Weight: 362.302

Synonyms:5-aminocarbonyl-2-chloro-N₄-(1,2,2,6,6-pentamethylpiperidin-4-yl)-4-pyrimidineamine hydrochloride

Chemical Property of 5-aminocarbonyl-2-chloro-N₄-(1,2,2,6,6-pentamethylpiperidin-4-yl)-4-pyrimidineamine hydrochloride

Chemical Property:

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Technology Process of 5-aminocarbonyl-2-chloro-N₄-(1,2,2,6,6-pentamethylpiperidin-4-yl)-4-pyrimidineamine hydrochloride

There total 1 articles about 5-aminocarbonyl-2-chloro-N₄-(1,2,2,6,6-pentamethylpiperidin-4-yl)-4-pyrimidineamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

4-amino-1,2,2,6,6-pentamethylpiperidine (40327-96-6) + 2,4-dichloro-pyrimidine-5-carboxylic acid amide (1240390-28-6) → 5-aminocarbonyl-2-chloro-N4-(1,2,2,6,6-pentamethylpiperidin-4-yl)-4-pyrimidineamine hydrochloride (1309831-09-1)

Guidance literature:

In methanol; water; at 0 - 20 ℃; for 48h;

Reference yield: 53.0%

1-(5-amino-2-cyclopropyl-4-fluorophenyl)-4-methyl-1H-tetrazol-5(4H)-one (1309831-16-0) + 5-aminocarbonyl-2-chloro-N4-(1,2,2,6,6-pentamethylpiperidin-4-yl)-4-pyrimidineamine hydrochloride (1309831-09-1) → C26H35FN10O2 (1309833-24-6)

Guidance literature:

1-(5-amino-2-cyclopropyl-4-fluorophenyl)-4-methyl-1H-tetrazol-5(4H)-one; 5-aminocarbonyl-2-chloro-N₄-(1,2,2,6,6-pentamethylpiperidin-4-yl)-4-pyrimidineamine hydrochloride; With toluene-4-sulfonic acid; In isopropyl alcohol; at 100 ℃; Sealed vial;

With sodium hydroxide; In ethyl acetate;

Reference yield:

1-(5-amino-2-cyclopropyl-4-fluorophenyl)-4-methyl-1H-tetrazol-5(4H)-one (1309831-16-0) + 5-aminocarbonyl-2-chloro-N4-(1,2,2,6,6-pentamethylpiperidin-4-yl)-4-pyrimidineamine hydrochloride (1309831-09-1) → 2-[4-Cyclopropyl-2-fluoro-5-(4-methyl-5-oxo-4,5-dihydro-tetrazol-1-yl)-phenylamino]-4-(1,2,2,6,6-pentamethyl-piperidin-4-ylamino)-pyrimidine-5-carbonitrile (1309831-20-6)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / isopropyl alcohol / 100 °C / Sealed vial

2: triethylamine; trifluoroacetic anhydride / tetrahydrofuran / 3.5 h / -50 - 0 °C / Inert atmosphere

With toluene-4-sulfonic acid; triethylamine; trifluoroacetic anhydride; In tetrahydrofuran; isopropyl alcohol;

upstream raw materials:

4-amino-1,2,2,6,6-pentamethylpiperidine

2,4-dichloro-pyrimidine-5-carboxylic acid amide

Downstream raw materials:

2-[4-Cyclopropyl-2-fluoro-5-(4-methyl-5-oxo-4,5-dihydro-tetrazol-1-yl)-phenylamino]-4-(1,2,2,6,6-pentamethyl-piperidin-4-ylamino)-pyrimidine-5-carbonitrile

C₂₆H₃₅FN₁₀O₂

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