ethyl 3-[4-(3'-(1-adamantyl)-4'-benzyloxyphenyl)-3-chlorophenyl]propanoate

Base Information

Chemical Name:ethyl 3-[4-(3'-(1-adamantyl)-4'-benzyloxyphenyl)-3-chlorophenyl]propanoate
CAS No.:1308280-00-3
Molecular Formula:C₃₄H₃₇ClO₃
Molecular Weight:529.119
Hs Code.:

Synonyms:ethyl 3-[4-(3'-(1-adamantyl)-4'-benzyloxyphenyl)-3-chlorophenyl]propanoate

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Chemical Property of ethyl 3-[4-(3'-(1-adamantyl)-4'-benzyloxyphenyl)-3-chlorophenyl]propanoate

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Technology Process of ethyl 3-[4-(3'-(1-adamantyl)-4'-benzyloxyphenyl)-3-chlorophenyl]propanoate

There total 5 articles about ethyl 3-[4-(3'-(1-adamantyl)-4'-benzyloxyphenyl)-3-chlorophenyl]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1261878-70-9
ethyl 3-(4-bromo-3-chlorophenyl)propanoate

: 221137-01-5
3-(1-adamantyl)-4-benzyloxyphenylboronic acid

: 1308280-00-3
ethyl 3-[4-(3'-(1-adamantyl)-4'-benzyloxyphenyl)-3-chlorophenyl]propanoate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; water; for 20h; Inert atmosphere; Reflux;
DOI:10.1021/jm200051z

Reference yield:

: 57418-97-0
4‐bromo‐3‐chlorobenzonitrile

: 1308280-00-3
ethyl 3-[4-(3'-(1-adamantyl)-4'-benzyloxyphenyl)-3-chlorophenyl]propanoate

Guidance literature:: Multi-step reaction with 4 steps

1: diisobutylaluminium hydride / dichloromethane; toluene / -78 - 20 °C

2: toluene / 17 h / Reflux

3: palladium 10% on activated carbon; hydrogen / ethyl acetate / 23 h

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; water / 20 h / Inert atmosphere; Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; diisobutylaluminium hydride; sodium carbonate; In 1,2-dimethoxyethane; dichloromethane; water; ethyl acetate; toluene; 2: Wittig reaction / 4: Suzuki coupling;
DOI:10.1021/jm200051z

Reference yield:

: 1308279-93-7
thyl (E)-4-Bromo-3-chlorocinnamate

: 1308280-00-3
ethyl 3-[4-(3'-(1-adamantyl)-4'-benzyloxyphenyl)-3-chlorophenyl]propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 23 h

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; water / 20 h / Inert atmosphere; Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; sodium carbonate; In 1,2-dimethoxyethane; water; ethyl acetate; 2: Suzuki coupling;
DOI:10.1021/jm200051z