57418-97-0Relevant articles and documents
Heteroatom-substituted analogues of orphan nuclear receptor small heterodimer partner ligand and apoptosis inducer (E)-4-[3-(1-adamantyl)-4- hydroxyphenyl]-3-chlorocinnamic acid
Xia, Zebin,Farhana, Lulu,Correa, Ricardo G.,Das, Jayanta K.,Castro, David J.,Yu, Jinghua,Oshima, Robert G.,Reed, John C.,Fontana, Joseph A.,Dawson, Marcia I.
experimental part, p. 3793 - 3816 (2011/08/06)
(E)-4-[3'-(1-Adamantyl)-4'-hydroxyphenyl]-3-chlorocinnamic acid (3-Cl-AHPC) induces the cell cycle arrest and apoptosis of cancer cells. Because its pharmacologic properties-solubility, bioavailability, and toxicity-required improvement for translation, s
Synthesis and antiprotozoal activity of dicationic 3,5-diphenylisoxazoles
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Page/Page column 24-26, (2010/11/24)
Novel dicationic 3,5-diphenylisoxazole compounds are described. Synthetic routes to these novel compounds are provided. Several of the compounds displayed in vitro activity versus Trypanosoma brucei brucei and Plasmodium falciparum comparable to that of furamidine. A majority of the novel compounds also were less toxic to VERO cells than furamidine.