Piperidine, 1-((trimethylsilyl)methyl)-

Base Information

• Chemical Name: Piperidine, 1-((trimethylsilyl)methyl)-
• CAS No.: 17877-17-7
• Molecular Formula: C9H21 N Si
• Molecular Weight: 171.358
• Hs Code.: 2933399090
• Mol file: 17877-17-7.mol

Synonyms:NSC 83834

Chemical Property of Piperidine, 1-((trimethylsilyl)methyl)-

Chemical Property:

• Vapor Pressure: 0.952mmHg at 25°C
• Boiling Point: 179.2°Cat760mmHg
• Flash Point: 62.2°C
• PSA: 3.24000
• Density: 0.84g/cm³
• LogP: 2.70590

Purity/Quality:

99%min ^*data from raw suppliers

1-[(trimethylsilyl)methyl]-Piperidine 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Piperidine, 1-((trimethylsilyl)methyl)-

There total 4 articles about Piperidine, 1-((trimethylsilyl)methyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

piperidine (110-89-4) + Chloromethyltrimethylsilane (2344-80-1) → 1-((trimethylsilyl)methyl)piperidine (17877-17-7)

Guidance literature:

In dimethyl sulfoxide; at 80 - 90 ℃; for 4h;

Reference yield: 55.0%

C15H25NSSi + methyllithium (917-54-4) → 1-((trimethylsilyl)methyl)piperidine (17877-17-7)

Guidance literature:

In tetrahydrofuran; at -78 - -30 ℃; for 20h;

DOI:10.1002/anie.201702410

Reference yield: 52.0%

benzyldimethyl(piperidinomethyl)silane + methyllithium (917-54-4) → 1-((trimethylsilyl)methyl)piperidine (17877-17-7)

Guidance literature:

In tetrahydrofuran; at -78 - -30 ℃; for 20h;

DOI:10.1002/anie.201702410

upstream raw materials:

piperidine

Chloromethyltrimethylsilane

methyllithium

Downstream raw materials:

N-(4-Pentenyl)-N-trimethylsilylmethylanilin

2-(Dimethyl-piperidin-1-ylmethyl-silanyl)-1-phenyl-ethanol

1-Cyclohexyl-2-(dimethyl-piperidin-1-ylmethyl-silanyl)-ethanol

N-Formylpiperidine

Refernces

• 1、 Schwarz, J. Luca,Kleinmans, Roman,Paulisch, Tiffany O.,Glorius, Frank. "1,2-Amino Alcohols via Cr/Photoredox Dual-Catalyzed Addition of α-Amino Carbanion Equivalents to Carbonyls". supporting information. p. 2168 - 2174. Retrieved 2020/03/03.
• 2、 Berton, Mateo,Mello, Rossella,Acerete, Rafael,González Núnez, María Elena. "Photolysis of Tertiary Amines in the Presence of CO2: The Paths to Formic Acid, α-Amino Acids, and 1,2-Diamines". . p. 96 - 103. Retrieved 2018/02/19.