(2R,8S,9R)-8-benzyloxy-9-(tert-butyldiphenylsilanyloxymethyl)-2-methoxy-2-vinyl-2,3,4,5,6,7,8,9-octahydrooxonine

Base Information

Chemical Name:(2R,8S,9R)-8-benzyloxy-9-(tert-butyldiphenylsilanyloxymethyl)-2-methoxy-2-vinyl-2,3,4,5,6,7,8,9-octahydrooxonine
CAS No.:1172121-96-8
Molecular Formula:C₃₅H₄₆O₄Si
Molecular Weight:558.833
Hs Code.:

Synonyms:(2R,8S,9R)-8-benzyloxy-9-(tert-butyldiphenylsilanyloxymethyl)-2-methoxy-2-vinyl-2,3,4,5,6,7,8,9-octahydrooxonine

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Chemical Property of (2R,8S,9R)-8-benzyloxy-9-(tert-butyldiphenylsilanyloxymethyl)-2-methoxy-2-vinyl-2,3,4,5,6,7,8,9-octahydrooxonine

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Technology Process of (2R,8S,9R)-8-benzyloxy-9-(tert-butyldiphenylsilanyloxymethyl)-2-methoxy-2-vinyl-2,3,4,5,6,7,8,9-octahydrooxonine

There total 1 articles about (2R,8S,9R)-8-benzyloxy-9-(tert-butyldiphenylsilanyloxymethyl)-2-methoxy-2-vinyl-2,3,4,5,6,7,8,9-octahydrooxonine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 1172121-53-7
(2R,8S,9R)-8-benzyloxy-9-(tert-butyldiphenylsilanyloxymethyl)-2-methoxy-2,3,4,5,6,7,8,9-octahydrooxonine-2-carbaldehyde

: 1779-49-3
Methyltriphenylphosphonium bromide

: 1172121-96-8
(2R,8S,9R)-8-benzyloxy-9-(tert-butyldiphenylsilanyloxymethyl)-2-methoxy-2-vinyl-2,3,4,5,6,7,8,9-octahydrooxonine

Guidance literature:: Methyltriphenylphosphonium bromide; With sodium hydride; In dimethyl sulfoxide; at 20 ℃; for 0.0833333h; Inert atmosphere;

(2R,8S,9R)-8-benzyloxy-9-(tert-butyldiphenylsilanyloxymethyl)-2-methoxy-2,3,4,5,6,7,8,9-octahydrooxonine-2-carbaldehyde; In dimethyl sulfoxide; at 20 ℃; for 0.666667h; Inert atmosphere;
DOI:10.1016/j.tetasy.2009.03.010

Reference yield: 81.0%

: 1172121-96-8
(2R,8S,9R)-8-benzyloxy-9-(tert-butyldiphenylsilanyloxymethyl)-2-methoxy-2-vinyl-2,3,4,5,6,7,8,9-octahydrooxonine

: 1172121-98-0
(2R,8S,9R)-8-benzyloxy-9-hydroxymethyl-2-methoxy-2-vinyl-2,3,4,5,6,7,8,9-octahydrooxonine

Guidance literature:: (2R,8S,9R)-8-benzyloxy-9-(tert-butyldiphenylsilanyloxymethyl)-2-methoxy-2-vinyl-2,3,4,5,6,7,8,9-octahydrooxonine; With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 20 ℃; for 18.5h; Inert atmosphere;

With water; In tetrahydrofuran; diethyl ether;
DOI:10.1016/j.tetasy.2009.03.010