Propionic acid (E)-(S)-4-(tert-butyl-diphenyl-silanyloxy)-1-[3-(5,9-dihydro-6,8-dioxa-benzocyclohepten-7-yl)-propyl]-but-2-enyl ester

Base Information

Chemical Name:Propionic acid (E)-(S)-4-(tert-butyl-diphenyl-silanyloxy)-1-[3-(5,9-dihydro-6,8-dioxa-benzocyclohepten-7-yl)-propyl]-but-2-enyl ester
CAS No.:137445-63-7
Molecular Formula:C₃₅H₄₄O₅Si
Molecular Weight:572.817
Hs Code.:

Synonyms:Propionic acid (E)-(S)-4-(tert-butyl-diphenyl-silanyloxy)-1-[3-(5,9-dihydro-6,8-dioxa-benzocyclohepten-7-yl)-propyl]-but-2-enyl ester

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Chemical Property of Propionic acid (E)-(S)-4-(tert-butyl-diphenyl-silanyloxy)-1-[3-(5,9-dihydro-6,8-dioxa-benzocyclohepten-7-yl)-propyl]-but-2-enyl ester

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Technology Process of Propionic acid (E)-(S)-4-(tert-butyl-diphenyl-silanyloxy)-1-[3-(5,9-dihydro-6,8-dioxa-benzocyclohepten-7-yl)-propyl]-but-2-enyl ester

There total 8 articles about Propionic acid (E)-(S)-4-(tert-butyl-diphenyl-silanyloxy)-1-[3-(5,9-dihydro-6,8-dioxa-benzocyclohepten-7-yl)-propyl]-but-2-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 79-03-8
propionyl chloride

: (E)-(S)-1-(tert-Butyl-diphenyl-silanyloxy)-7-(5,9-dihydro-6,8-dioxa-benzocyclohepten-7-yl)-hept-2-en-4-ol

: 137445-63-7
Propionic acid (E)-(S)-4-(tert-butyl-diphenyl-silanyloxy)-1-[3-(5,9-dihydro-6,8-dioxa-benzocyclohepten-7-yl)-propyl]-but-2-enyl ester

Guidance literature:: With pyridine; In dichloromethane; at 0 - 25 ℃;
DOI:10.1016/S0040-4039(00)92272-X

Reference yield:

: 542-28-9,26354-94-9
3,4,5,6-tetrahydro-2H-pyran-2-one

: 137445-63-7
Propionic acid (E)-(S)-4-(tert-butyl-diphenyl-silanyloxy)-1-[3-(5,9-dihydro-6,8-dioxa-benzocyclohepten-7-yl)-propyl]-but-2-enyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 99 percent

2: 72 percent / PCC, 3 Angstroem mol. sieves, Celite / CH₂Cl₂ / 25 °C

3: 93 percent / PPTS / benzene / Heating

4: (S)-BINAL-H / tetrahydrofuran / -100 - -78 °C

5: 100 percent / Bu₄NF / tetrahydrofuran / 25 °C

6: 97 percent / sodium bis(2-methoxyethoxy)aluminum hydride / tetrahydrofuran / 0 - 25 °C

7: 93 percent / imidazole / dimethylformamide; CH₂Cl₂ / 0 - 25 °C

8: 97 percent / pyridine / CH₂Cl₂ / 0 - 25 °C

With pyridine; 1H-imidazole; (-)-(S)-BINAL-H; 3 A molecular sieve; Celite; tetrabutyl ammonium fluoride; pyridinium p-toluenesulfonate; sodium bis(2-methoxyethoxy)aluminium dihydride; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1016/S0040-4039(00)92272-X

Reference yield:

: (E)-(S)-7-(5,9-Dihydro-6,8-dioxa-benzocyclohepten-7-yl)-hept-2-ene-1,4-diol

: 137445-63-7
Propionic acid (E)-(S)-4-(tert-butyl-diphenyl-silanyloxy)-1-[3-(5,9-dihydro-6,8-dioxa-benzocyclohepten-7-yl)-propyl]-but-2-enyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / imidazole / dimethylformamide; CH₂Cl₂ / 0 - 25 °C

2: 97 percent / pyridine / CH₂Cl₂ / 0 - 25 °C

With pyridine; 1H-imidazole; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)92272-X