5-(3-acetoxyprop-1-ynyl)-2-[4-(benzyloxy)-3-methoxyphenyl]-7-methoxybenzofuran

Base Information

Chemical Name:5-(3-acetoxyprop-1-ynyl)-2-[4-(benzyloxy)-3-methoxyphenyl]-7-methoxybenzofuran
CAS No.:515814-08-1
Molecular Formula:C₂₈H₂₄O₆
Molecular Weight:456.495
Hs Code.:

Synonyms:5-(3-acetoxyprop-1-ynyl)-2-[4-(benzyloxy)-3-methoxyphenyl]-7-methoxybenzofuran

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Chemical Property of 5-(3-acetoxyprop-1-ynyl)-2-[4-(benzyloxy)-3-methoxyphenyl]-7-methoxybenzofuran

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Technology Process of 5-(3-acetoxyprop-1-ynyl)-2-[4-(benzyloxy)-3-methoxyphenyl]-7-methoxybenzofuran

There total 4 articles about 5-(3-acetoxyprop-1-ynyl)-2-[4-(benzyloxy)-3-methoxyphenyl]-7-methoxybenzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 627-09-8
Propargyl acetate

: 515814-05-8
2-[4-(benzyloxy)-3-methoxyphenyl]-5-bromo-7-methoxybenzofuran

: 515814-08-1
5-(3-acetoxyprop-1-ynyl)-2-[4-(benzyloxy)-3-methoxyphenyl]-7-methoxybenzofuran

Guidance literature:: With copper(l) iodide; bis(benzonitrile)palladium(II) dichloride; triethylamine; tri tert-butylphosphoniumtetrafluoroborate; In N,N-dimethyl-formamide; at 90 ℃; for 20h;
DOI:10.1055/s-0029-1219224

Reference yield:

: 56897-51-9
5-bromo-7-methoxy-2-nitrobenzofuran

: 515814-08-1
5-(3-acetoxyprop-1-ynyl)-2-[4-(benzyloxy)-3-methoxyphenyl]-7-methoxybenzofuran

Guidance literature:: Multi-step reaction with 3 steps

1: 74 percent / PBr₃ / 5 h / 175 °C

2: 96 percent / tetrakis(triphenylphosphine)palladium⁽⁰⁾ / dioxane / 5 h / 145 °C

3: 66 percent / tetrakis(triphenylphosphine)palladium⁽⁰⁾; CuI; Et₃N / 5 h / 90 °C

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; phosphorus tribromide; triethylamine; In 1,4-dioxane; 2: Stille coupling / 3: Sonogashira reaction;
DOI:10.1021/jo020653t

Reference yield:

: 5034-74-2
5-bromo-3-methoxysalicylaldehyde

: 515814-08-1
5-(3-acetoxyprop-1-ynyl)-2-[4-(benzyloxy)-3-methoxyphenyl]-7-methoxybenzofuran

Guidance literature:: Multi-step reaction with 4 steps

1: 74 percent / PBr₃ / 5 h / 175 °C

2: 96 percent / tetrakis(triphenylphosphine)palladium⁽⁰⁾ / dioxane / 5 h / 145 °C

3: 66 percent / tetrakis(triphenylphosphine)palladium⁽⁰⁾; CuI; Et₃N / 5 h / 90 °C

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; phosphorus tribromide; triethylamine; In 1,4-dioxane; 3: Stille coupling / 4: Sonogashira reaction;
DOI:10.1021/jo020653t