2-[4-(benzyloxy)-3-methoxyphenyl]-5-bromo-7-methoxybenzofuran

Base Information

• Chemical Name: 2-[4-(benzyloxy)-3-methoxyphenyl]-5-bromo-7-methoxybenzofuran
• CAS No.: 515814-05-8
• Molecular Formula: C₂₃H₁₉BrO₄
• Molecular Weight: 439.305
• Mol file: 515814-05-8.mol

Synonyms:2-[4-(benzyloxy)-3-methoxyphenyl]-5-bromo-7-methoxybenzofuran

Chemical Property of 2-[4-(benzyloxy)-3-methoxyphenyl]-5-bromo-7-methoxybenzofuran

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[4-(benzyloxy)-3-methoxyphenyl]-5-bromo-7-methoxybenzofuran

There total 11 articles about 2-[4-(benzyloxy)-3-methoxyphenyl]-5-bromo-7-methoxybenzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

5-bromo-7-methoxy-2-bromobenzofuran (515814-03-6) + (4-benzyloxy-3-methoxyphenyl)trimethylstannane → 2-[4-(benzyloxy)-3-methoxyphenyl]-5-bromo-7-methoxybenzofuran (515814-05-8)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; at 145 ℃; for 5h;

DOI:10.1021/jo020653t

Reference yield: 94.0%

2-[4-(benzyloxy)-3-methoxystyryl]-4-bromo-6-methoxyphenol (1233720-57-4) → 2-[4-(benzyloxy)-3-methoxyphenyl]-5-bromo-7-methoxybenzofuran (515814-05-8)

Guidance literature:

2-[4-(benzyloxy)-3-methoxystyryl]-4-bromo-6-methoxyphenol; With potassium carbonate; In tetrahydrofuran; for 0.166667h;

With iodine; In tetrahydrofuran; at 20 ℃;

DOI:10.1055/s-0029-1219224 DOI:10.1055/s-0029-1218826

Reference yield: 67.0%

3-methoxy-4-benzyloxybenzoyl chloride (1486-52-8) + 2-hydroxy-3-methoxy-5-bromobenzyltriphenylphosphonium chloride → 2-[4-(benzyloxy)-3-methoxyphenyl]-5-bromo-7-methoxybenzofuran (515814-05-8)

Guidance literature:

With triethylamine; In toluene; at 110 ℃;

DOI:10.1016/j.tet.2016.09.068

upstream raw materials:

5-bromo-7-methoxy-2-bromobenzofuran

5-bromo-7-methoxy-2-nitrobenzofuran

5-bromo-3-methoxysalicylaldehyde

2-[4-(benzyloxy)-3-methoxystyryl]-4-bromo-6-methoxyphenol

Downstream raw materials:

5-(3-acetoxyprop-1-ynyl)-2-[4-(benzyloxy)-3-methoxyphenyl]-7-methoxybenzofuran

5-(2-(ethoxycarbonyl)-E-ethenyl)-7-methoxy-2-(3-methoxy-4-benzyloxyphenyl)benzofuran

5-((2-methoxycarbonyl)ethyl)-7-methoxy-2-(3'-methoxy-4'-hydroxyphenyl)benzofuran

2-(4-hydroxy-3-methoxyphenyl)-5-(3-hydroxypropyl)-7-methoxybenzofurane