Chemical Property of [4-({6-[Allyl(methyl)amino]hexyl}oxy)-2-fluorophenyl](4-bromophenyl)methanone
Chemical Property:
- Vapor Pressure:5.02E-11mmHg at 25°C
- Boiling Point:522.8°Cat760mmHg
- PKA:8.88±0.50(Predicted)
- Flash Point:270°C
- PSA：29.54000
- Density:1.235g/cm3
- LogP:5.87620
- Storage Temp.:2-8°C
- XLogP3:6.1
- Hydrogen Bond Donor Count:0
- Hydrogen Bond Acceptor Count:4
- Rotatable Bond Count:12
- Exact Mass:447.12092
- Heavy Atom Count:28
- Complexity:468
- Purity/Quality:
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≥95% *data from raw suppliers
Ro 48-8071 *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CN(CCCCCCOC1=CC(=C(C=C1)C(=O)C2=CC=C(C=C2)Br)F)CC=C
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Description
Oxidosqualene cyclase (OSC) is a microsomal enzyme that catalyzes the cyclization of monooxidosqualene to lanosterol in the cholesterol synthetic pathway. Ro 48-8071 is an inhibitor of oxidosqualene cyclase (OSC) that has low-density lipoprotein (LDL) cholesterol lowering activity similar to the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) inhibitor simvastatin. It inhibits OSC from human liver microsomes and HepG2 cells with IC50 values of approximately 6.5 nM and 1.5 nM, respectively. Ro 48-8071 lowered LDL cholesterol ~40% in hamsters at a dose of 150 μg/kg without affecting high-density lipoprotein levels and with no sign of liver toxicity. Ro 48-8071 increases cytochrome P3A mRNA and protein levels in primary rat and murine hepatocyte cultures with a maximal effect at 30 μM.
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Uses
Ro 48-8071 is an inhibitor of oxidosqualene cyclase.
