5(R)-[[[I(S)-[[I(R)-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-I-phenyl-2-propenyl]amino]methyl]-5-ethenyl-2-pyrrolidinone 4-methylbenzenesulfonate

Base Information

Chemical Name:5(R)-[[[I(S)-[[I(R)-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-I-phenyl-2-propenyl]amino]methyl]-5-ethenyl-2-pyrrolidinone 4-methylbenzenesulfonate
CAS No.:1178515-21-3
Molecular Formula:C₇H₈O₃S*C₂₇H₂₈F₆N₂O₂
Molecular Weight:698.727
Hs Code.:

5(R)-[[[I(S)-[[I(R)-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-I-phenyl-2-propenyl]amino]methyl]-5-ethenyl-2-pyrrolidinone 4-methylbenzenesulfonate

Synonyms:5(R)-[[[I(S)-[[I(R)-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-I-phenyl-2-propenyl]amino]methyl]-5-ethenyl-2-pyrrolidinone 4-methylbenzenesulfonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5(R)-[[[I(S)-[[I(R)-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-I-phenyl-2-propenyl]amino]methyl]-5-ethenyl-2-pyrrolidinone 4-methylbenzenesulfonate

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Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of 5(R)-[[[I(S)-[[I(R)-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-I-phenyl-2-propenyl]amino]methyl]-5-ethenyl-2-pyrrolidinone 4-methylbenzenesulfonate

There total 11 articles about 5(R)-[[[I(S)-[[I(R)-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-I-phenyl-2-propenyl]amino]methyl]-5-ethenyl-2-pyrrolidinone 4-methylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1178515-20-2
C₂₇H₂₈F₆N₂O₂

: 104-15-4
toluene-4-sulfonic acid

: 1178515-21-3
5(R)-[[[I(S)-[[I(R)-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-I-phenyl-2-propenyl]amino]methyl]-5-ethenyl-2-pyrrolidinone 4-methylbenzenesulfonate

Guidance literature:: With water; In isopropyl alcohol; at 25 ℃; for 9h;

Reference yield:

: 1214741-20-4
C₁₂H₁₇NO₃

: 1178515-21-3
5(R)-[[[I(S)-[[I(R)-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-I-phenyl-2-propenyl]amino]methyl]-5-ethenyl-2-pyrrolidinone 4-methylbenzenesulfonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium tri(t-butoxy)aluminum hydride / tetrahydrofuran / 14 h / -20 - 0 °C / Inert atmosphere

1.2: 2 h / 0 - 20 °C / Inert atmosphere

2.1: triethylamine / water; ethanol / 4 h / 25 °C

3.1: ethanol; toluene / Reflux

4.1: sodium tris(acetoxy)borohydride; acetic acid / toluene / 6 h / 25 °C

5.1: water / isopropyl alcohol / 9 h / 25 °C

With lithium tri(t-butoxy)aluminum hydride; water; sodium tris(acetoxy)borohydride; acetic acid; triethylamine; In tetrahydrofuran; ethanol; water; isopropyl alcohol; toluene;

Reference yield:

: 171284-84-7
(2R,5S)-2-t-butyl-1-aza-3-oxabicyclo<3.3.0>octane-4,8-dione

: 1178515-21-3
5(R)-[[[I(S)-[[I(R)-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-I-phenyl-2-propenyl]amino]methyl]-5-ethenyl-2-pyrrolidinone 4-methylbenzenesulfonate

Guidance literature:: Multi-step reaction with 7 steps

1.1: copper(l) chloride; 1,3-dimethyl-2-imidazolidinone; lithium hexamethyldisilazane; chloro-trimethyl-silane / tetrahydrofuran / 0.5 h / -60 - 10 °C / Inert atmosphere

1.2: 3.67 h / 5 - 25 °C

2.1: sodium hexamethyldisilazane / toluene / 1 h / 10 °C

2.2: 10 °C

3.1: lithium tri(t-butoxy)aluminum hydride / tetrahydrofuran / 14 h / -20 - 0 °C / Inert atmosphere

3.2: 2 h / 0 - 20 °C / Inert atmosphere

4.1: triethylamine / water; ethanol / 4 h / 25 °C

5.1: ethanol; toluene / Reflux

6.1: sodium tris(acetoxy)borohydride; acetic acid / toluene / 6 h / 25 °C

7.1: water / isopropyl alcohol / 9 h / 25 °C

With 1,3-dimethyl-2-imidazolidinone; chloro-trimethyl-silane; lithium tri(t-butoxy)aluminum hydride; water; sodium hexamethyldisilazane; sodium tris(acetoxy)borohydride; acetic acid; triethylamine; copper(l) chloride; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; water; isopropyl alcohol; toluene;