Technology Process of 5(R)-[[[I(S)-[[I(R)-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-I-phenyl-2-propenyl]amino]methyl]-5-ethenyl-2-pyrrolidinone 4-methylbenzenesulfonate
There total 11 articles about 5(R)-[[[I(S)-[[I(R)-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-I-phenyl-2-propenyl]amino]methyl]-5-ethenyl-2-pyrrolidinone 4-methylbenzenesulfonate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
water;
In
isopropyl alcohol;
at 25 ℃;
for 9h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: lithium tri(t-butoxy)aluminum hydride / tetrahydrofuran / 14 h / -20 - 0 °C / Inert atmosphere
1.2: 2 h / 0 - 20 °C / Inert atmosphere
2.1: triethylamine / water; ethanol / 4 h / 25 °C
3.1: ethanol; toluene / Reflux
4.1: sodium tris(acetoxy)borohydride; acetic acid / toluene / 6 h / 25 °C
5.1: water / isopropyl alcohol / 9 h / 25 °C
With
lithium tri(t-butoxy)aluminum hydride; water; sodium tris(acetoxy)borohydride; acetic acid; triethylamine;
In
tetrahydrofuran; ethanol; water; isopropyl alcohol; toluene;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: copper(l) chloride; 1,3-dimethyl-2-imidazolidinone; lithium hexamethyldisilazane; chloro-trimethyl-silane / tetrahydrofuran / 0.5 h / -60 - 10 °C / Inert atmosphere
1.2: 3.67 h / 5 - 25 °C
2.1: sodium hexamethyldisilazane / toluene / 1 h / 10 °C
2.2: 10 °C
3.1: lithium tri(t-butoxy)aluminum hydride / tetrahydrofuran / 14 h / -20 - 0 °C / Inert atmosphere
3.2: 2 h / 0 - 20 °C / Inert atmosphere
4.1: triethylamine / water; ethanol / 4 h / 25 °C
5.1: ethanol; toluene / Reflux
6.1: sodium tris(acetoxy)borohydride; acetic acid / toluene / 6 h / 25 °C
7.1: water / isopropyl alcohol / 9 h / 25 °C
With
1,3-dimethyl-2-imidazolidinone; chloro-trimethyl-silane; lithium tri(t-butoxy)aluminum hydride; water; sodium hexamethyldisilazane; sodium tris(acetoxy)borohydride; acetic acid; triethylamine; copper(l) chloride; lithium hexamethyldisilazane;
In
tetrahydrofuran; ethanol; water; isopropyl alcohol; toluene;