171284-84-7

Usage

Uses

Used in Medicinal Chemistry:
(3R,7aS)-3-tert-butyldihydropyrrolo[1,2-c]oxazole-1,5(3H,6H)-dione is used as a potential pharmaceutical candidate for developing novel drugs with therapeutic activities. Its unique structural features, including the dihydropyrrole and oxazole rings, as well as the tertiary butyl group, may contribute to its biological activity and make it a promising candidate for further research and development.
Used in Organic Synthesis:
In the field of organic synthesis, (3R,7aS)-3-tert-butyldihydropyrrolo[1,2-c]oxazole-1,5(3H,6H)-dione serves as a valuable building block for the preparation of more complex molecules. Its heterocyclic structure and functional groups can be utilized in various synthetic routes, enabling the creation of diverse chemical entities with potential applications in various industries, such as pharmaceuticals, agrochemicals, and materials science.

Upstream product

• 630-19-3 pivalaldehyde 
• 98-79-3 L-Pyroglutamic acid 

Downstream Products

• 1214741-19-1 C₁₁H₁₅NO₄ 
• 1214741-23-7 C₂₇H₂₆F₆N₂O₂ 
• 1178515-20-2 C₂₇H₂₈F₆N₂O₂ 
• 1214741-22-6 (S)-5-oxo-2-vinylpyrrolidine-2-carbaldehyde 
• 1214741-20-4 C₁₂H₁₇NO₃ 
• 858102-79-1 Rolapitant hydrochloride 
• 1178515-21-3 5(R)-[[[I(S)-[[I(R)-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-I-phenyl-2-propenyl]amino]methyl]-5-ethenyl-2-pyrrolidinone 4-methylbenzenesulfonate 

Relevant academic research and scientific papers

Self Reproduction of Chirality in Pyroglutamates: Reactions at α- Position with Electrophiles

Condensation of pyroglutamic acid with trimethylacetaldehyde gave a bicyclic derivative which on deprotonation with LiHMDS and reaction with electrophiles gives chiral α-substituted pyroglutamate derivatives.

Collective Total Synthesis of (-)-Lundurines A-C

A collective asymmetric total synthesis of lundurines A-C using l-pyroglutamic acid derived from the chiral pool is described. The key steps include a tandem reductive amination/lactamization sequence to introduce the pyrrolidinone ring, a palladium-catalyzed intramolecular direct C-H vinylation of indole to construct the crucial polyhydroazocine ring, and a Lewis acid promoted formal [3 + 2] cycloaddition/N2 extrusion process to install the polysubstituted cyclopropyl ring.

Process and Intermediates for the Synthesis of 8-[-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one Compounds

This application discloses a novel process to synthesize 8-[{1-(3,5-Bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds, which may be used, for example, as NK-1 inhibitor compounds in pharmaceutical preparations

Acid catalyzed condensation of pyroglutamic acid with arylaldehydes: Synthesis of (3R, 7aS)-3-aryldihydropyrrolo[1, 2-c] oxazol-1, 5(3H, 6H) dione

A simple strategy for the synthesis of (3R, 7aS)-3-aryldihydropyrrolo [1, 2-c] oxazol-1, 5(3H, 6H)-diones as bicyclic hemiaminals through acid catalyzed condensation of pyroglutamic acid with arylaldehydes has been described. This could be useful for the