ethyl (R_S,1S,2S)-2-[(1R)-1-(p-tolylsulfinyl)-2-(trimethylsilyl)ethyl]cyclopropanecarboxylate

Base Information

• Chemical Name: ethyl (R_S,1S,2S)-2-[(1R)-1-(p-tolylsulfinyl)-2-(trimethylsilyl)ethyl]cyclopropanecarboxylate
• CAS No.: 191422-44-3
• Molecular Formula: C₁₈H₂₈O₃SSi
• Molecular Weight: 352.57
• Mol file: 191422-44-3.mol

Synonyms:ethyl (R_S,1S,2S)-2-[(1R)-1-(p-tolylsulfinyl)-2-(trimethylsilyl)ethyl]cyclopropanecarboxylate

Chemical Property of ethyl (R_S,1S,2S)-2-[(1R)-1-(p-tolylsulfinyl)-2-(trimethylsilyl)ethyl]cyclopropanecarboxylate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of ethyl (R_S,1S,2S)-2-[(1R)-1-(p-tolylsulfinyl)-2-(trimethylsilyl)ethyl]cyclopropanecarboxylate

There total 2 articles about ethyl (R_S,1S,2S)-2-[(1R)-1-(p-tolylsulfinyl)-2-(trimethylsilyl)ethyl]cyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

4-bromo-trans-crotonic acid ethyl ester (37746-78-4) + (RS)-p-Tolyl β-(trimethylsilyl)ethyl sulfoxide (153123-09-2) → ethyl (RS,1S,2S)-2-[(1R)-1-(p-tolylsulfinyl)-2-(trimethylsilyl)ethyl]cyclopropanecarboxylate (191422-44-3)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.25h;

DOI:10.1055/s-1997-6144

Reference yield: 80.0%

4-bromo-trans-crotonic acid ethyl ester (37746-78-4) + p-tolyl α-lithio-β-(trimethylsilyl)ethyl sulfoxide → ethyl (RS,1S,2S)-2-[(1R)-1-(p-tolylsulfinyl)-2-(trimethylsilyl)ethyl]cyclopropanecarboxylate (191422-44-3)

Guidance literature:

In tetrahydrofuran; at -78 ℃; for 0.25h;

DOI:10.1021/jo991635n

Reference yield: 56.0%

ethyl (RS,1S,2S)-2-[(1R)-1-(p-tolylsulfinyl)-2-(trimethylsilyl)ethyl]cyclopropanecarboxylate (191422-44-3) → (1S,2R)-ethyl 2-vinylcyclopropanecarboxylate (200013-10-1)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃; for 1h;

DOI:10.1021/jo991635n

upstream raw materials:

4-bromo-trans-crotonic acid ethyl ester

(R_S)-p-Tolyl β-(trimethylsilyl)ethyl sulfoxide

Downstream raw materials:

(1S,2R)-ethyl 2-vinylcyclopropanecarboxylate