tetraethyl (4-(2-fluorophenyl)pyridazine-3,6-diyl)bis(methylene)diphosphonate

Base Information

Chemical Name:tetraethyl (4-(2-fluorophenyl)pyridazine-3,6-diyl)bis(methylene)diphosphonate
CAS No.:1396424-49-9
Molecular Formula:C₂₀H₂₉FN₂O₆P₂
Molecular Weight:474.406
Hs Code.:

Synonyms:tetraethyl (4-(2-fluorophenyl)pyridazine-3,6-diyl)bis(methylene)diphosphonate

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Chemical Property of tetraethyl (4-(2-fluorophenyl)pyridazine-3,6-diyl)bis(methylene)diphosphonate

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Technology Process of tetraethyl (4-(2-fluorophenyl)pyridazine-3,6-diyl)bis(methylene)diphosphonate

There total 4 articles about tetraethyl (4-(2-fluorophenyl)pyridazine-3,6-diyl)bis(methylene)diphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 766-49-4
(2-fluorophenyl)acetylene

: 1396424-49-9
tetraethyl (4-(2-fluorophenyl)pyridazine-3,6-diyl)bis(methylene)diphosphonate

Guidance literature:: Multi-step reaction with 4 steps

1: 1,4-dioxane / Reflux

2: lithium aluminium tetrahydride / 60 °C

3: thionyl chloride / dichloromethane / 0.33 h / 20 °C

4: 18 h / 110 °C

With lithium aluminium tetrahydride; thionyl chloride; In 1,4-dioxane; dichloromethane; 1: |Diels-Alder Cycloaddition;
DOI:10.1021/jm300653b

Reference yield:

: 1396423-78-1
dimethyl 4-(2-Fluorophenyl)pyridazine-3,6-dicarboxylate

: 1396424-49-9
tetraethyl (4-(2-fluorophenyl)pyridazine-3,6-diyl)bis(methylene)diphosphonate

Guidance literature:: Multi-step reaction with 3 steps

1: lithium aluminium tetrahydride / 60 °C

2: thionyl chloride / dichloromethane / 0.33 h / 20 °C

3: 18 h / 110 °C

With lithium aluminium tetrahydride; thionyl chloride; In dichloromethane;
DOI:10.1021/jm300653b

Reference yield:

: 1396424-11-5
(4-(2-fluorophenyl)pyridazine-3,6-diyl)dimethanol

: 1396424-49-9
tetraethyl (4-(2-fluorophenyl)pyridazine-3,6-diyl)bis(methylene)diphosphonate

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / dichloromethane / 0.33 h / 20 °C

2: 18 h / 110 °C

With thionyl chloride; In dichloromethane;
DOI:10.1021/jm300653b