4,4′-(1E,1′E)-2,2′-(4-(2-fluorophenyl)pyridazine-3,6-diyl)bis-(ethene-2,1-diyl)bis(N,N-dimethylaniline)

Base Information

Chemical Name:4,4′-(1E,1′E)-2,2′-(4-(2-fluorophenyl)pyridazine-3,6-diyl)bis-(ethene-2,1-diyl)bis(N,N-dimethylaniline)
CAS No.:1396424-85-3
Molecular Formula:C₃₀H₂₉FN₄
Molecular Weight:464.585
Hs Code.:

Synonyms:4,4′-(1E,1′E)-2,2′-(4-(2-fluorophenyl)pyridazine-3,6-diyl)bis-(ethene-2,1-diyl)bis(N,N-dimethylaniline)

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Chemical Property of 4,4′-(1E,1′E)-2,2′-(4-(2-fluorophenyl)pyridazine-3,6-diyl)bis-(ethene-2,1-diyl)bis(N,N-dimethylaniline)

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Technology Process of 4,4′-(1E,1′E)-2,2′-(4-(2-fluorophenyl)pyridazine-3,6-diyl)bis-(ethene-2,1-diyl)bis(N,N-dimethylaniline)

There total 4 articles about 4,4′-(1E,1′E)-2,2′-(4-(2-fluorophenyl)pyridazine-3,6-diyl)bis-(ethene-2,1-diyl)bis(N,N-dimethylaniline) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1396424-49-9
tetraethyl (4-(2-fluorophenyl)pyridazine-3,6-diyl)bis(methylene)diphosphonate

: 100-10-7
4-dimethylamino-benzaldehyde

: 1396424-85-3
4,4′-(1E,1′E)-2,2′-(4-(2-fluorophenyl)pyridazine-3,6-diyl)bis-(ethene-2,1-diyl)bis(N,N-dimethylaniline)

Guidance literature:: tetraethyl (4-(2-fluorophenyl)pyridazine-3,6-diyl)bis(methylene)diphosphonate; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

4-dimethylamino-benzaldehyde; In N,N-dimethyl-formamide; at 20 ℃; for 18h;
DOI:10.1021/jm300653b

Reference yield:

: 766-49-4
(2-fluorophenyl)acetylene

: 1396424-85-3
4,4′-(1E,1′E)-2,2′-(4-(2-fluorophenyl)pyridazine-3,6-diyl)bis-(ethene-2,1-diyl)bis(N,N-dimethylaniline)

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1,4-dioxane / Reflux

2.1: lithium aluminium tetrahydride / 60 °C

3.1: thionyl chloride / dichloromethane / 0.33 h / 20 °C

4.1: 18 h / 110 °C

5.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C

5.2: 18 h / 20 °C

With lithium aluminium tetrahydride; thionyl chloride; sodium hydride; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; 1.1: |Diels-Alder Cycloaddition / 5.1: |Horner-Wadsworth-Emmons Olefination / 5.2: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1021/jm300653b

Reference yield:

: 1396423-78-1
dimethyl 4-(2-Fluorophenyl)pyridazine-3,6-dicarboxylate

: 1396424-85-3
4,4′-(1E,1′E)-2,2′-(4-(2-fluorophenyl)pyridazine-3,6-diyl)bis-(ethene-2,1-diyl)bis(N,N-dimethylaniline)

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium aluminium tetrahydride / 60 °C

2.1: thionyl chloride / dichloromethane / 0.33 h / 20 °C

3.1: 18 h / 110 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C

4.2: 18 h / 20 °C

With lithium aluminium tetrahydride; thionyl chloride; sodium hydride; In dichloromethane; N,N-dimethyl-formamide; 4.1: |Horner-Wadsworth-Emmons Olefination / 4.2: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1021/jm300653b