2,2-dimethyl-N-[6-(4-methyl-piperazin-1-yl)-4-o-tolyl-pyridin-3-yl]-propionamide

Base Information

Chemical Name:2,2-dimethyl-N-[6-(4-methyl-piperazin-1-yl)-4-o-tolyl-pyridin-3-yl]-propionamide
CAS No.:290297-23-3
Molecular Formula:C₂₂H₃₀N₄O
Molecular Weight:366.506
Hs Code.:

Synonyms:2,2-dimethyl-N-[6-(4-methyl-piperazin-1-yl)-4-o-tolyl-pyridin-3-yl]-propionamide

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Chemical Property of 2,2-dimethyl-N-[6-(4-methyl-piperazin-1-yl)-4-o-tolyl-pyridin-3-yl]-propionamide

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Technology Process of 2,2-dimethyl-N-[6-(4-methyl-piperazin-1-yl)-4-o-tolyl-pyridin-3-yl]-propionamide

There total 6 articles about 2,2-dimethyl-N-[6-(4-methyl-piperazin-1-yl)-4-o-tolyl-pyridin-3-yl]-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 290297-22-2
N-[4-iodo-6-(4-methyl-piperazin-1-yl)-pyridin-3-yl]-2,2-dimethyl-propionamide

: 16419-60-6
2-Methylphenylboronic acid

: 290297-23-3
2,2-dimethyl-N-[6-(4-methyl-piperazin-1-yl)-4-o-tolyl-pyridin-3-yl]-propionamide

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In toluene; at 80 ℃;
DOI:10.1016/j.bmcl.2005.11.047

Reference yield:

: 290297-21-1
2,2-dimethyl-N-[6-(4-methyl-piperazin-1-yl)-pyridin-3-yl]-propionamide

: 290297-23-3
2,2-dimethyl-N-[6-(4-methyl-piperazin-1-yl)-4-o-tolyl-pyridin-3-yl]-propionamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-BuLi; TMEDA; 2,2,6,6-tetramethylpiperidine / tetrahydrofuran / -78 - -30 °C

1.2: I₂ / tetrahydrofuran / -78 - 0 °C

2.1: Pd(PPh₃)4; Na₂CO₃ / toluene / 80 °C

With 2,2,6,6-tetramethyl-piperidine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; sodium carbonate; In tetrahydrofuran; toluene; 2.1: Suzuki coupling;
DOI:10.1016/j.bmcl.2005.11.047

Reference yield:

: 109-01-3
1-methyl-piperazine

: 290297-23-3
2,2-dimethyl-N-[6-(4-methyl-piperazin-1-yl)-4-o-tolyl-pyridin-3-yl]-propionamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrahydrofuran / Heating

2.1: hydrogen / Pd/C / methanol / 45 °C / 760 Torr

3.1: Et₃N / tetrahydrofuran / 20 °C

4.1: n-BuLi; TMEDA; 2,2,6,6-tetramethylpiperidine / tetrahydrofuran / -78 - -30 °C

4.2: I₂ / tetrahydrofuran / -78 - 0 °C

5.1: Pd(PPh₃)4; Na₂CO₃ / toluene / 80 °C

With 2,2,6,6-tetramethyl-piperidine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; hydrogen; sodium carbonate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; toluene; 5.1: Suzuki coupling;
DOI:10.1016/j.bmcl.2005.11.047