1-Benzenesulfonyl-3-(2-tert-butyl-4,5-dihydro-[1,3]dioxepin-5-yl)-1H-indole

Base Information

Chemical Name:1-Benzenesulfonyl-3-(2-tert-butyl-4,5-dihydro-[1,3]dioxepin-5-yl)-1H-indole
CAS No.:205238-28-4
Molecular Formula:C₂₃H₂₅NO₄S
Molecular Weight:411.522
Hs Code.:

Synonyms:1-Benzenesulfonyl-3-(2-tert-butyl-4,5-dihydro-[1,3]dioxepin-5-yl)-1H-indole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-Benzenesulfonyl-3-(2-tert-butyl-4,5-dihydro-[1,3]dioxepin-5-yl)-1H-indole

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Technology Process of 1-Benzenesulfonyl-3-(2-tert-butyl-4,5-dihydro-[1,3]dioxepin-5-yl)-1H-indole

There total 1 articles about 1-Benzenesulfonyl-3-(2-tert-butyl-4,5-dihydro-[1,3]dioxepin-5-yl)-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 53586-63-3
2-tert-butyl-4,7-dihydro-1,3-dioxepine

: 80360-14-1
3-iodo-1-phenylsulfonyl-1H-indole

: 205238-28-4
1-Benzenesulfonyl-3-(2-tert-butyl-4,5-dihydro-[1,3]dioxepin-5-yl)-1H-indole

Guidance literature:: With palladium diacetate; tetrabutyl-ammonium chloride; potassium acetate; triphenylphosphine; In N,N-dimethyl-formamide; at 80 ℃;
DOI:10.3987/com-97-s39

Reference yield: 53.0%

: 205238-28-4
1-Benzenesulfonyl-3-(2-tert-butyl-4,5-dihydro-[1,3]dioxepin-5-yl)-1H-indole

: 205238-29-5
2-(1-Benzenesulfonyl-1H-indol-3-yl)-propane-1,3-diol

Guidance literature:: With sodium tetrahydroborate; ozone; In ethanol; at -78 - 0 ℃;
DOI:10.3987/com-97-s39

Reference yield:

: 205238-28-4
1-Benzenesulfonyl-3-(2-tert-butyl-4,5-dihydro-[1,3]dioxepin-5-yl)-1H-indole

: (R)-3-(1-Benzenesulfonyl-1H-indol-3-yl)-butane-1,2-diol

Guidance literature:: Multi-step reaction with 10 steps

1: 53 percent / O₃, sodium borohydride / ethanol / -78 - 0 °C

2: 82 percent / lipase AK / benzene / Ambient temperature

3: 90 percent / Et₃N, 4-DMAP / CH₂Cl₂ / Ambient temperature

4: 1.) NaBH₄; 2.) lithium aluminum hydride / 1.) DMSO, 60 deg C; 2.) THF, 0 deg C

5: 87 percent / i-Pr₂NEt, 4-DMAP / Ambient temperature

6: 94 percent / 18-crown-6 / dimethylsulfoxide / 60 °C

7: 1.) diisobutylaluminum hydride; 2.) 10percent HCl / CH₂Cl₂; hexane

8: NaBH₄ / methanol / 0 °C

9: 1.) o-nitrophenylselenylcyanide, tri-n-butylphosphine; 2.) hydrogen peroxide / 1.) THF, r.t.; 2.) THF, r.t.

10: 100 percent / AD-mix-α, aq. t-BuOH / 0 °C

With hydrogenchloride; dmap; sodium tetrahydroborate; AD-mix-α; lithium aluminium tetrahydride; ortho-nitrophenyl selenocyanate; lipase AK; 18-crown-6 ether; tributylphosphine; dihydrogen peroxide; diisobutylaluminium hydride; ozone; triethylamine; N-ethyl-N,N-diisopropylamine; tert-butyl alcohol; In methanol; ethanol; hexane; dichloromethane; dimethyl sulfoxide; benzene;
DOI:10.3987/com-97-s39