4-[(4-bromo-2,5-dichloro-phenoxy)-ethoxy-thiophosphorylamino]-butyric acid

Base Information

• Chemical Name: 4-[(4-bromo-2,5-dichloro-phenoxy)-ethoxy-thiophosphorylamino]-butyric acid
• CAS No.: 475476-65-4
• Molecular Formula: C₁₂H₁₅BrCl₂NO₄PS
• Molecular Weight: 451.105

Synonyms:4-[(4-bromo-2,5-dichloro-phenoxy)-ethoxy-thiophosphorylamino]-butyric acid

Chemical Property of 4-[(4-bromo-2,5-dichloro-phenoxy)-ethoxy-thiophosphorylamino]-butyric acid

Chemical Property:

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Technology Process of 4-[(4-bromo-2,5-dichloro-phenoxy)-ethoxy-thiophosphorylamino]-butyric acid

There total 2 articles about 4-[(4-bromo-2,5-dichloro-phenoxy)-ethoxy-thiophosphorylamino]-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

Thiophosphorochloridic acid O-(4-bromo-2,5-dichloro-phenyl) ester O'-ethyl ester (55999-27-4) + 4-amino-n-butyric acid (56-12-2) → 4-[(4-bromo-2,5-dichloro-phenoxy)-ethoxy-thiophosphorylamino]-butyric acid (475476-65-4)

Guidance literature:

With potassium hydroxide; In methanol; for 0.0833333h;

DOI:10.1021/jf025703+

Reference yield:

4-bromo-2,5-dichlorophenol (1940-42-7,79151-08-9) → 4-[(4-bromo-2,5-dichloro-phenoxy)-ethoxy-thiophosphorylamino]-butyric acid (475476-65-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 44 percent / K₂CO₃ / acetonitrile / 1 h / 20 °C

2: 33 percent / KOH / methanol / 0.08 h

With potassium hydroxide; potassium carbonate; In methanol; acetonitrile;

DOI:10.1021/jf025703+

Reference yield: 43.0%

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + 4-[(4-bromo-2,5-dichloro-phenoxy)-ethoxy-thiophosphorylamino]-butyric acid (475476-65-4) → 4-[(4-bromo-2,5-dichloro-phenoxy)-ethoxy-thiophosphorylamino]-butyric acid 2,5-dioxo-pyrrolidin-1-yl ester

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; for 3h;

DOI:10.1021/jf025703+

upstream raw materials:

Thiophosphorochloridic acid O-(4-bromo-2,5-dichloro-phenyl) ester O'-ethyl ester

4-amino-n-butyric acid

4-bromo-2,5-dichlorophenol

Downstream raw materials:

1-hydroxy-pyrrolidine-2,5-dione

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