N-[(R)-1-(5-bromo-2-fluoro-phenyl)-2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-3-chloro-N-(4-methoxy-benzyl)-propionamide

Base Information

Chemical Name:N-[(R)-1-(5-bromo-2-fluoro-phenyl)-2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-3-chloro-N-(4-methoxy-benzyl)-propionamide
CAS No.:1346146-73-3
Molecular Formula:C₂₆H₃₆BrClFNO₃Si
Molecular Weight:573.018
Hs Code.:

Synonyms:N-[(R)-1-(5-bromo-2-fluoro-phenyl)-2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-3-chloro-N-(4-methoxy-benzyl)-propionamide

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Chemical Property of N-[(R)-1-(5-bromo-2-fluoro-phenyl)-2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-3-chloro-N-(4-methoxy-benzyl)-propionamide

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Technology Process of N-[(R)-1-(5-bromo-2-fluoro-phenyl)-2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-3-chloro-N-(4-methoxy-benzyl)-propionamide

There total 8 articles about N-[(R)-1-(5-bromo-2-fluoro-phenyl)-2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-3-chloro-N-(4-methoxy-benzyl)-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 1266785-98-1
[(R)-1-(5-bromo-2-fluoro-phenyl)-2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-(4-methoxy-benzyl)-amine

: 625-36-5
2-chloropropionyl chloride

: 1346146-73-3
N-[(R)-1-(5-bromo-2-fluoro-phenyl)-2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-3-chloro-N-(4-methoxy-benzyl)-propionamide

Guidance literature:: With sodium hydrogencarbonate; In chloroform; at 0 - 20 ℃; for 16h;

Reference yield:

: 1266785-96-9
(R)-2-(5-bromo-2-fluoro-phenyl)-2-(4-methoxy-benzylamino)-propan-1-ol

: 1346146-73-3
N-[(R)-1-(5-bromo-2-fluoro-phenyl)-2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-3-chloro-N-(4-methoxy-benzyl)-propionamide

Guidance literature:: Multi-step reaction with 2 steps

1: dmap; triethylamine / dichloromethane / 16 h / 20 °C

2: sodium hydrogencarbonate / chloroform / 16 h / 0 - 20 °C

With dmap; sodium hydrogencarbonate; triethylamine; In dichloromethane; chloroform;

Reference yield:

: 198477-89-3
1-(5-bromo-2-fluorophenyl)ethan-1-one

: 1346146-73-3
N-[(R)-1-(5-bromo-2-fluoro-phenyl)-2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-3-chloro-N-(4-methoxy-benzyl)-propionamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 20 °C

1.2: 1.5 h / 20 °C / cooling with ice

2.1: iodine / ethyl acetate; acetonitrile / 16.75 h / 0 - 20 °C / Inert atmosphere; Darkness

3.1: silver tetrafluoroborate / N,N-dimethyl-formamide; tert-butyl alcohol / 16 h / 80 °C

4.1: Chiralpak AD / n-heptane; ethanol

5.1: lithium hydroxide monohydrate / ethanol; water / 100 °C

6.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 0.5 h / 20 °C

7.1: dmap; triethylamine / dichloromethane / 16 h / 20 °C

8.1: sodium hydrogencarbonate / chloroform / 16 h / 0 - 20 °C

With dmap; silver tetrafluoroborate; lithium hydroxide monohydrate; potassium tert-butylate; iodine; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; triethylamine; In tetrahydrofuran; ethanol; n-heptane; dichloromethane; chloroform; water; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;