3-chloro-5-trifluoromethyl-pyridine-2-carboxylic acid [4-fluoro-3-((R)-3-methyl-5-oxo-[1,4]oxazepan-3-yl)phenyl]amide

Base Information

Chemical Name:3-chloro-5-trifluoromethyl-pyridine-2-carboxylic acid [4-fluoro-3-((R)-3-methyl-5-oxo-[1,4]oxazepan-3-yl)phenyl]amide
CAS No.:1346146-79-9
Molecular Formula:C₁₉H₁₆ClF₄N₃O₃
Molecular Weight:445.801
Hs Code.:

Synonyms:3-chloro-5-trifluoromethyl-pyridine-2-carboxylic acid [4-fluoro-3-((R)-3-methyl-5-oxo-[1,4]oxazepan-3-yl)phenyl]amide

Suppliers and Price of 3-chloro-5-trifluoromethyl-pyridine-2-carboxylic acid [4-fluoro-3-((R)-3-methyl-5-oxo-[1,4]oxazepan-3-yl)phenyl]amide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-chloro-5-trifluoromethyl-pyridine-2-carboxylic acid [4-fluoro-3-((R)-3-methyl-5-oxo-[1,4]oxazepan-3-yl)phenyl]amide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-chloro-5-trifluoromethyl-pyridine-2-carboxylic acid [4-fluoro-3-((R)-3-methyl-5-oxo-[1,4]oxazepan-3-yl)phenyl]amide

There total 16 articles about 3-chloro-5-trifluoromethyl-pyridine-2-carboxylic acid [4-fluoro-3-((R)-3-methyl-5-oxo-[1,4]oxazepan-3-yl)phenyl]amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 80194-68-9
3-chloro-5-trifluoromethylpyridine-2-carboxylic acid

: 1346146-78-8
(R)-3-(5-amino-2-fluoro-phenyl)-3-methyl-[1,4]oxazepan-5-one hydrochloride

: 1346146-79-9
3-chloro-5-trifluoromethyl-pyridine-2-carboxylic acid [4-fluoro-3-((R)-3-methyl-5-oxo-[1,4]oxazepan-3-yl)phenyl]amide

Guidance literature:: With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 16h;

Reference yield:

: 198477-89-3
1-(5-bromo-2-fluorophenyl)ethan-1-one

: 1346146-79-9
3-chloro-5-trifluoromethyl-pyridine-2-carboxylic acid [4-fluoro-3-((R)-3-methyl-5-oxo-[1,4]oxazepan-3-yl)phenyl]amide

Guidance literature:: Multi-step reaction with 13 steps

1.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 20 °C

1.2: 1.5 h / 20 °C / cooling with ice

2.1: iodine / ethyl acetate; acetonitrile / 16.75 h / 0 - 20 °C / Inert atmosphere; Darkness

3.1: silver tetrafluoroborate / N,N-dimethyl-formamide; tert-butyl alcohol / 16 h / 80 °C

4.1: Chiralpak AD / n-heptane; ethanol

5.1: lithium hydroxide monohydrate / ethanol; water / 100 °C

6.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 0.5 h / 20 °C

7.1: dmap; triethylamine / dichloromethane / 16 h / 20 °C

8.1: sodium hydrogencarbonate / chloroform / 16 h / 0 - 20 °C

9.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 0 - 20 °C

10.1: trifluoroacetic acid; trifluorormethanesulfonic acid / methoxybenzene / 24 h / 20 - 73 °C

11.1: sodium t-butanolate / tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; tert-butyl XPhos / toluene / 16 h / 105 °C / Inert atmosphere; Sealed vial

12.1: hydrogenchloride / 1,4-dioxane; water / 16 h / 20 °C

13.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 16 h / 0 - 20 °C

With hydrogenchloride; dmap; silver tetrafluoroborate; lithium hydroxide monohydrate; trifluorormethanesulfonic acid; potassium tert-butylate; tetrabutyl ammonium fluoride; iodine; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium t-butanolate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; tert-butyl XPhos; In tetrahydrofuran; 1,4-dioxane; ethanol; n-heptane; dichloromethane; chloroform; water; ethyl acetate; methoxybenzene; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; acetonitrile; tert-butyl alcohol;

Reference yield:

: 1266785-96-9
(R)-2-(5-bromo-2-fluoro-phenyl)-2-(4-methoxy-benzylamino)-propan-1-ol

: 1346146-79-9
3-chloro-5-trifluoromethyl-pyridine-2-carboxylic acid [4-fluoro-3-((R)-3-methyl-5-oxo-[1,4]oxazepan-3-yl)phenyl]amide

Guidance literature:: Multi-step reaction with 7 steps

1: dmap; triethylamine / dichloromethane / 16 h / 20 °C

2: sodium hydrogencarbonate / chloroform / 16 h / 0 - 20 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 0 - 20 °C

4: trifluoroacetic acid; trifluorormethanesulfonic acid / methoxybenzene / 24 h / 20 - 73 °C

5: sodium t-butanolate / tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; tert-butyl XPhos / toluene / 16 h / 105 °C / Inert atmosphere; Sealed vial

6: hydrogenchloride / 1,4-dioxane; water / 16 h / 20 °C

7: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 16 h / 0 - 20 °C

With hydrogenchloride; dmap; trifluorormethanesulfonic acid; tetrabutyl ammonium fluoride; sodium hydrogencarbonate; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium t-butanolate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; tert-butyl XPhos; In tetrahydrofuran; 1,4-dioxane; dichloromethane; chloroform; water; methoxybenzene; N,N-dimethyl-formamide; toluene;