ethyl (2S)-2-[(3-oxo-7-oxaspiro[3.5]non-1-en-1-yl)amino]-3-{4-[(3,5-dichloroisonicotinoyl)amino]phenyl}propanoate

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Chemical Name:ethyl (2S)-2-[(3-oxo-7-oxaspiro[3.5]non-1-en-1-yl)amino]-3-{4-[(3,5-dichloroisonicotinoyl)amino]phenyl}propanoate
CAS No.:455262-48-3
Molecular Formula:C₂₅H₂₅Cl₂N₃O₅
Molecular Weight:518.397
Hs Code.:

Synonyms:ethyl (2S)-2-[(3-oxo-7-oxaspiro[3.5]non-1-en-1-yl)amino]-3-{4-[(3,5-dichloroisonicotinoyl)amino]phenyl}propanoate

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Chemical Property of ethyl (2S)-2-[(3-oxo-7-oxaspiro[3.5]non-1-en-1-yl)amino]-3-{4-[(3,5-dichloroisonicotinoyl)amino]phenyl}propanoate

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Technology Process of ethyl (2S)-2-[(3-oxo-7-oxaspiro[3.5]non-1-en-1-yl)amino]-3-{4-[(3,5-dichloroisonicotinoyl)amino]phenyl}propanoate

There total 5 articles about ethyl (2S)-2-[(3-oxo-7-oxaspiro[3.5]non-1-en-1-yl)amino]-3-{4-[(3,5-dichloroisonicotinoyl)amino]phenyl}propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 263276-28-4
N-isonicotinoyl-(L)-4-aminophenylalanine

: 455264-53-6
7-oxaspiro[3.5]nonane-1,3-dione

: 455262-48-3
ethyl (2S)-2-[(3-oxo-7-oxaspiro[3.5]non-1-en-1-yl)amino]-3-{4-[(3,5-dichloroisonicotinoyl)amino]phenyl}propanoate

Guidance literature:: In tetrahydrofuran; at 20 ℃;
DOI:10.1021/ol034701n

Reference yield:

: 5337-03-1
tetrahydro-2H-pyran-4-carboxylic acid

: 455262-48-3
ethyl (2S)-2-[(3-oxo-7-oxaspiro[3.5]non-1-en-1-yl)amino]-3-{4-[(3,5-dichloroisonicotinoyl)amino]phenyl}propanoate

Guidance literature:: Multi-step reaction with 4 steps

1: oxalyl chloride; DMF / CH₂Cl₂ / 1 h

2: 59 percent / triethylamine / diethyl ether; hexane / 264 h / 45 °C

3: 87 percent / hydrochloric acid / H₂O / 24 h / 20 °C

4: 91 percent / tetrahydrofuran / 20 °C

With hydrogenchloride; oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; water;
DOI:10.1021/ol034701n

Reference yield:

: 40191-32-0
tetrahydro-2H-pyran-4-carbonylchloride

: 455262-48-3
ethyl (2S)-2-[(3-oxo-7-oxaspiro[3.5]non-1-en-1-yl)amino]-3-{4-[(3,5-dichloroisonicotinoyl)amino]phenyl}propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 59 percent / triethylamine / diethyl ether; hexane / 264 h / 45 °C

2: 87 percent / hydrochloric acid / H₂O / 24 h / 20 °C

3: 91 percent / tetrahydrofuran / 20 °C

With hydrogenchloride; triethylamine; In tetrahydrofuran; diethyl ether; hexane; water;
DOI:10.1021/ol034701n