(3S,5S,6R,8S)-8-allyl-6-(3-chloro-2-fluorophenyl)-5-(4-chlorophenyl )-3-cyclopropyl-8-methyl-2 ,3, 5,6 ,7,8-hexahydrooxazolo[3,2-a]pyridin-4-ium 4-methylbenzenesulfonate

Base Information

Chemical Name:(3S,5S,6R,8S)-8-allyl-6-(3-chloro-2-fluorophenyl)-5-(4-chlorophenyl )-3-cyclopropyl-8-methyl-2 ,3, 5,6 ,7,8-hexahydrooxazolo[3,2-a]pyridin-4-ium 4-methylbenzenesulfonate
CAS No.:1623432-66-5
Molecular Formula:C₇H₇O₃S*C₂₆H₂₇Cl₂FNO
Molecular Weight:630.608
Hs Code.:

(3S,5S,6R,8S)-8-allyl-6-(3-chloro-2-fluorophenyl)-5-(4-chlorophenyl )-3-cyclopropyl-8-methyl-2 ,3, 5,6 ,7,8-hexahydrooxazolo[3,2-a]pyridin-4-ium 4-methylbenzenesulfonate

Synonyms:(3S,5S,6R,8S)-8-allyl-6-(3-chloro-2-fluorophenyl)-5-(4-chlorophenyl )-3-cyclopropyl-8-methyl-2 ,3, 5,6 ,7,8-hexahydrooxazolo[3,2-a]pyridin-4-ium 4-methylbenzenesulfonate

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Chemical Property of (3S,5S,6R,8S)-8-allyl-6-(3-chloro-2-fluorophenyl)-5-(4-chlorophenyl )-3-cyclopropyl-8-methyl-2 ,3, 5,6 ,7,8-hexahydrooxazolo[3,2-a]pyridin-4-ium 4-methylbenzenesulfonate

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Technology Process of (3S,5S,6R,8S)-8-allyl-6-(3-chloro-2-fluorophenyl)-5-(4-chlorophenyl )-3-cyclopropyl-8-methyl-2 ,3, 5,6 ,7,8-hexahydrooxazolo[3,2-a]pyridin-4-ium 4-methylbenzenesulfonate

There total 14 articles about (3S,5S,6R,8S)-8-allyl-6-(3-chloro-2-fluorophenyl)-5-(4-chlorophenyl )-3-cyclopropyl-8-methyl-2 ,3, 5,6 ,7,8-hexahydrooxazolo[3,2-a]pyridin-4-ium 4-methylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1623432-64-3
(3S,5R,6S)-3-allyl-6-(4-chloro-3-fluorophenyl)-5-(3-chlorophenyl)-1-((S)-1-cyclopropyl-2-hydroxyethyl)-3-methylpiperidin-2-one

: 104-15-4
toluene-4-sulfonic acid

: 1623432-66-5
(3S,5S,6R,8S)-8-allyl-6-(3-chloro-2-fluorophenyl)-5-(4-chlorophenyl )-3-cyclopropyl-8-methyl-2 ,3, 5,6 ,7,8-hexahydrooxazolo[3,2-a]pyridin-4-ium 4-methylbenzenesulfonate

Guidance literature:: In toluene; for 4h; Inert atmosphere; Reflux; Dean-Stark;
DOI:10.1021/jm501550p

Reference yield:

: 1623432-61-0
(3S,5R,6R)-3-allyl-6-(4-chloro-3-fluorophenyl)-5-(3-chlorophenyl)-3-methyltetrahydro-2H-pyran-2-one

: 1623432-66-5
(3S,5S,6R,8S)-8-allyl-6-(3-chloro-2-fluorophenyl)-5-(4-chlorophenyl )-3-cyclopropyl-8-methyl-2 ,3, 5,6 ,7,8-hexahydrooxazolo[3,2-a]pyridin-4-ium 4-methylbenzenesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1: 100 °C

2: p-toluenesulfonylanhydride; 2,6-dimethylpyridine / dichloromethane / 24 h / 0 °C / Reflux

3: toluene / 4 h / Dean-Stark; Reflux

With 2,6-dimethylpyridine; p-toluenesulfonylanhydride; In dichloromethane; toluene;

Reference yield:

: 4124-41-8
p-toluenesulfonylanhydride

: 1640128-68-2
(2S)-2-((2R,3R)-3-(4-chloro-3-fluorophenyl)-2-(3-chlorophenyl)-3-hydroxypropyl)-N-((S)-1-cyclopropyl-2-hydroxyethyl)-2-methylpent-4-enamide

: 1623432-66-5
(3S,5S,6R,8S)-8-allyl-6-(3-chloro-2-fluorophenyl)-5-(4-chlorophenyl )-3-cyclopropyl-8-methyl-2 ,3, 5,6 ,7,8-hexahydrooxazolo[3,2-a]pyridin-4-ium 4-methylbenzenesulfonate

Guidance literature:: p-toluenesulfonylanhydride; (2S)-2-((2R,3R)-3-(4-chloro-3-fluorophenyl)-2-(3-chlorophenyl)-3-hydroxypropyl)-N-((S)-1-cyclopropyl-2-hydroxyethyl)-2-methylpent-4-enamide; In dichloromethane; at 0 ℃; for 0.166667h; Inert atmosphere;

With 2,6-dimethylpyridine; at 0 - 25 ℃; for 24h; Inert atmosphere; Reflux;
DOI:10.1021/jm501550p