403-17-8

Basic information

• Product Name: 4-Chloro-3-fluorobenzoic acid
• Synonyms: BUTTPARK 19\01-69;3-FLUORO-4-CHLOROBENZOIC ACID;4-CHLORO-3-FLUOROBENZOIC ACID;RARECHEM AL BO 1770;4-Chloro-3-Fluorobenzoic;4-Chloro-3-fluorobenzoic acid 97%;4-Chloro-3-fluorobenzoicacid97%
• CAS NO: 403-17-8
• Molecular Formula: C₇H₄ClFO₂
• Molecular Weight: 174.56
• Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Benzoic acid;Acids & Esters;Chlorine Compounds;Fluorine Compounds;carboxylic acid| alkyl chloride | alkyl Fluorine
• Mol File: 403-17-8.mol
• Article Data: 5

Chemical Properties

• Melting Point: 190-192°C
• Boiling Point: 287.4 °C at 760 mmHg
• Flash Point: 127.6 °C
• Appearance: /
• Density: 1.477 g/cm³
• Refractive Index: 1.497
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: DMSO, Methanol
• PKA: 3.63±0.10(Predicted)
• CAS DataBase Reference: 4-Chloro-3-fluorobenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-3-fluorobenzoic acid(403-17-8)
• EPA Substance Registry System: 4-Chloro-3-fluorobenzoic acid(403-17-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 22-24/25-37-26
• HazardClass: IRRITANT
• Hazardous Substances Data: 403-17-8(Hazardous Substances Data)

Usage

Chemical Properties

off-white powder

Uses

4-Chloro-3-fluorobenzoic Acid is a very useful precursor. It is a reagent used to synthesize 6-Hydroxy Albaconazole (H761395) which is a metabolite of Albaconazole (A511450), an antifungal agent as neuroprotectant.

InChI:InChI=1/C7H3BrF4O3S/c8-5-3-4(9)1-2-6(5)15-16(13,14)7(10,11)12/h1-3H

Upstream product

• 5527-94-6 1-chloro-2-fluoro-4-methylbenzene 
• 352-70-5 m-Fluorotoluene 
• 64-19-7 acetic acid 
• 108-44-1 1-amino-3-methylbenzene 
• 7758-19-2 sodium chlorite 
• 5329-14-6 aminosulfonic acid 
• 5527-95-7 4-chloro-3-fluorobenzaldehyde 
• 75-65-0 tert-butyl alcohol 
• 109-72-8 n-butyllithium 
• 60811-18-9 2-chloro-5-bromofluorobenzene 

Downstream Products

• 110888-15-8 4-chloro-3-fluorobenzonitrile 
• 64248-62-0 3,4-Difluorobenzonitrile 
• 202925-10-8 (4-chloro-3-fluorophenyl)methanol 

Relevant articles and documents

Photo-induced deep aerobic oxidation of alkyl aromatics

Oxidation is a major chemical process to produce oxygenated chemicals in both nature and the chemical industry. Presently, the industrial manufacture of benzoic acids and benzene polycarboxylic acids (BPCAs) is mainly based on the deep oxidation of polyalkyl benzene, which is somewhat suffering from environmental and economical disadvantage due to the formation of ozone-depleting MeBr and corrosion hazards of production equipment. In this report, photo-induced deep aerobic oxidation of (poly)alkyl benzene to benzene (poly)carboxylic acids was developed. CeCl3 was proved to be an efficient HAT (hydrogen atom transfer) catalyst in the presence of alcohol as both hydrogen and electron shuttle. Dioxygen (O2) was found as a sole terminal oxidant. In most cases, pure products were easily isolated by simple filtration, implying large-scale implementation advantages. The reaction provides an ideal protocol to produce valuable fine chemicals from naturally abundant petroleum feedstocks. [Figure not available: see fulltext.].

Diamine derivatives

A compound represented by the general formula (1): Q1-Q2-T0-N(R1)-Q3-N(R2)-T1-Q4??(1) wherein R1 and R2 are hydrogen atoms or the like; Q1 is a saturated or unsaturated, 5- or 6-membered cyclic hydrocarbon group which may be substituted, or the like; Q2 is a single bond or the like; Q3 is a group in which Q5 is an alkylene group having 1 to 8 carbon atoms, or the like; and T0 and T1 are carbonyl groups or the like; a salt thereof, a solvate thereof, or an N-oxide thereof. The compound is useful as an agent for preventing and/or treating cerebral infarction, cerebral embolism, myocardial infarction, angina pectoris, pulmonary infarction, pulmonary embolism, Buerger's disease, deep venous thrombosis, disseminated intravascular coagulation syndrome, thrombus formation after valve or joint replacement, thrombus formation and reocclusion after angioplasty, systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), thrombus formation during extracorporeal circulation, or blood clotting upon blood drawing.

4-benzoylisoxazole herbicides

The invention relates to 4-benzoylisoxazole derivatives of formula (I): STR1 wherein: R represents the hydrogen atom or a group --CO2 R4 ; R1 represents alkyl, haloalkyl or optionally substituted cycloalkyl; R2