403-17-8

Usage

Uses

Used in Pharmaceutical Industry:
4-Chloro-3-fluorobenzoic acid is used as a precursor for the synthesis of 6-Hydroxy Albaconazole (H761395), which is a metabolite of Albaconazole (A511450). Albaconazole is an antifungal agent with neuroprotective properties, making it a significant compound in the development of treatments for fungal infections and neurological disorders.
As a reagent in the synthesis of various pharmaceutical compounds, 4-Chloro-3-fluorobenzoic acid plays a crucial role in the development of new drugs and therapies, contributing to the advancement of medical research and healthcare.

InChI:InChI=1/C7H3BrF4O3S/c8-5-3-4(9)1-2-6(5)15-16(13,14)7(10,11)12/h1-3H

Upstream product

• 5527-95-7 4-chloro-3-fluorobenzaldehyde 
• 109-72-8 n-butyllithium 
• 60811-18-9 2-chloro-5-bromofluorobenzene 
• 7758-19-2 sodium chlorite 
• 5329-14-6 aminosulfonic acid 
• 75-65-0 tert-butyl alcohol 
• 108-44-1 1-amino-3-methylbenzene 
• 5527-94-6 1-chloro-2-fluoro-4-methylbenzene 
• 64-19-7 acetic acid 
• 352-70-5 m-Fluorotoluene 

Downstream Products

• 950848-65-4 C₂₆H₃₂ClFN₄O₃ 
• 153556-34-4 4-chloro-3-fluoro-2-(methylsulphenyl)benzoic acid 
• 170108-06-2 2-bromo-4-chloro-3-fluorobenzoic acid 
• 1187649-65-5 C₇H₂BrCl₂FO 
• 1187648-04-9 diethyl 2-((2-bromo-4-chloro-3-fluorophenyl)(hydroxy)methylene)malonate 
• 1429226-61-8 C₁₆H₁₂ClFN₂O₃S 
• 1430115-46-0 2-bromo-4-chloro-3-fluorobenzamide 
• 1430115-47-1 2-bromo-4-chloro-3-fluorobenzonitrile 
• 1430115-48-2 (E)-methyl 3-(3-chloro-6-cyano-2-fluorophenyl)acrylate 
• 1352423-57-4 (E)-3-(3-chloro-6-cyano-2-fluorophenyl)acrylic acid 
• 110888-15-8 4-chloro-3-fluorobenzonitrile 
• 64248-62-0 3,4-Difluorobenzonitrile 

Relevant academic research and scientific papers

Photo-induced deep aerobic oxidation of alkyl aromatics

Oxidation is a major chemical process to produce oxygenated chemicals in both nature and the chemical industry. Presently, the industrial manufacture of benzoic acids and benzene polycarboxylic acids (BPCAs) is mainly based on the deep oxidation of polyalkyl benzene, which is somewhat suffering from environmental and economical disadvantage due to the formation of ozone-depleting MeBr and corrosion hazards of production equipment. In this report, photo-induced deep aerobic oxidation of (poly)alkyl benzene to benzene (poly)carboxylic acids was developed. CeCl3 was proved to be an efficient HAT (hydrogen atom transfer) catalyst in the presence of alcohol as both hydrogen and electron shuttle. Dioxygen (O2) was found as a sole terminal oxidant. In most cases, pure products were easily isolated by simple filtration, implying large-scale implementation advantages. The reaction provides an ideal protocol to produce valuable fine chemicals from naturally abundant petroleum feedstocks. [Figure not available: see fulltext.].

Continuous production method for industrially preparing 2,3-difluorobenzotrifluoride and 3,4-difluorobenzonitrile

The invention discloses a continuous production method for industrially preparing 2,3-difluorobenzotrifluoride and 3,4-difluorobenzonitrile. The preparation process of the 2,3-difluorobenzotrifluoride comprises the preparation step of an intermediate raw material for benzene sulfonamide and benzenesulfonylurea herbicides, and the preparation process of the 3,4-difluorobenzonitrile comprises the preparation step of a cthalofop-butyl intermediate raw material. The method is suitable for industrial production; and compared with the prior art, the method has the advantages of low cost, high production method and less pollution.

Diamine derivatives

A compound represented by the general formula (1): Q1-Q2-T0-N(R1)-Q3-N(R2)-T1-Q4??(1) wherein R1 and R2 are hydrogen atoms or the like; Q1 is a saturated or unsaturated, 5- or 6-membered cyclic hydrocarbon group which may be substituted, or the like; Q2 is a single bond or the like; Q3 is a group in which Q5 is an alkylene group having 1 to 8 carbon atoms, or the like; and T0 and T1 are carbonyl groups or the like; a salt thereof, a solvate thereof, or an N-oxide thereof. The compound is useful as an agent for preventing and/or treating cerebral infarction, cerebral embolism, myocardial infarction, angina pectoris, pulmonary infarction, pulmonary embolism, Buerger's disease, deep venous thrombosis, disseminated intravascular coagulation syndrome, thrombus formation after valve or joint replacement, thrombus formation and reocclusion after angioplasty, systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), thrombus formation during extracorporeal circulation, or blood clotting upon blood drawing.

DIAMINE DERIVATIVES

A compound represented by the general formula (1):Q1-Q2-T0-N(R1)-Q3-N(R2)-T1-Q4 wherein R1 and R2 are hydrogen atoms or the like; Q1 is a saturated or unsaturated, 5- or 6- membered cyclic hydrocarbon group which may be substituted, or the like; Q2 is a single bond or the like; Q3 is a group in which Q5 is an alkylene group having 1 to 8 carbon atoms, or the like; and T0 and T1 are carbonyl groups or the like; a salt thereof, a solvate thereof, or an N-oxide thereof. The compound is useful as an agent for preventing and/or treating cerebral infarction, cerebral embolism, myocardial infarction, angina pectoris, pulmonary infarction, pulmonary embolism, Buerger's disease, deep venous thrombosis, disseminated intravascular coagulation syndrome, thrombus formation after valve or joint replacement, thrombus formation and reocclusion after angioplasty, systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), thrombus formation during extracorporeal circulation, or blood clotting upon blood drawing.

4-benzoylisoxazole herbicides

The invention relates to 4-benzoylisoxazole derivatives of formula (I): STR1 wherein: R represents the hydrogen atom or a group --CO2 R4 ; R1 represents alkyl, haloalkyl or optionally substituted cycloalkyl; R2