(+)-(2S)-Methyl 4,4-dibromo-2-methyl-2-<(4S)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl>-3-butenoate

Base Information

Chemical Name:(+)-(2S)-Methyl 4,4-dibromo-2-methyl-2-<(4S)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl>-3-butenoate
CAS No.:151074-94-1
Molecular Formula:C₁₅H₁₅Br₂NO₄
Molecular Weight:433.096
Hs Code.:

Synonyms:(+)-(2S)-Methyl 4,4-dibromo-2-methyl-2-<(4S)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl>-3-butenoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+)-(2S)-Methyl 4,4-dibromo-2-methyl-2-<(4S)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl>-3-butenoate

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Technology Process of (+)-(2S)-Methyl 4,4-dibromo-2-methyl-2-<(4S)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl>-3-butenoate

There total 5 articles about (+)-(2S)-Methyl 4,4-dibromo-2-methyl-2-<(4S)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl>-3-butenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 134627-50-2
(6S,7S)-7-<(4S)-2-Oxo-4-phenyl-1,3-oxazolidin-3-yl>-1-aza-5-oxabicyclo<4.2.0>octan-8-one

: 151074-94-1
(+)-(2S)-Methyl 4,4-dibromo-2-methyl-2-<(4S)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl>-3-butenoate

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / KHMDS / toluene; tetrahydrofuran; dimethylformamide / 1.) -78 deg C, 1 h, 2.) -78 deg C, 15 min

2: HCl / methanol / 24 h / 25 °C

3: 50 percent / 1 N HCl / tetrahydrofuran / 48 h / 25 °C

4: 1.) PPh₃ / 1.) CH₂Cl₂, 0 deg C, 30 min, 2.) 25 deg C, 20 h

With hydrogenchloride; potassium hexamethylsilazane; triphenylphosphine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo00074a016

Reference yield:

: (6S,7S)-7-((S)-2-Hydroxy-1-phenyl-ethylamino)-5-oxa-1-aza-bicyclo[4.2.0]octan-8-one

: 151074-94-1
(+)-(2S)-Methyl 4,4-dibromo-2-methyl-2-<(4S)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl>-3-butenoate

Guidance literature:: Multi-step reaction with 5 steps

1: i-Pr₂NEt / CH₂Cl₂ / 0.75 h / 0 °C

2: 80 percent / KHMDS / toluene; tetrahydrofuran; dimethylformamide / 1.) -78 deg C, 1 h, 2.) -78 deg C, 15 min

3: HCl / methanol / 24 h / 25 °C

4: 50 percent / 1 N HCl / tetrahydrofuran / 48 h / 25 °C

5: 1.) PPh₃ / 1.) CH₂Cl₂, 0 deg C, 30 min, 2.) 25 deg C, 20 h

With hydrogenchloride; potassium hexamethylsilazane; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo00074a016

Reference yield:

: (6S,7S)-7-((S)-2,2-Dimethyl-4-phenyl-oxazolidin-3-yl)-5-oxa-1-aza-bicyclo[4.2.0]octan-8-one

: 151074-94-1
(+)-(2S)-Methyl 4,4-dibromo-2-methyl-2-<(4S)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl>-3-butenoate

Guidance literature:: Multi-step reaction with 6 steps

1: 0.2 N HCl / tetrahydrofuran / 0.75 h / 25 °C

2: i-Pr₂NEt / CH₂Cl₂ / 0.75 h / 0 °C

3: 80 percent / KHMDS / toluene; tetrahydrofuran; dimethylformamide / 1.) -78 deg C, 1 h, 2.) -78 deg C, 15 min

4: HCl / methanol / 24 h / 25 °C

5: 50 percent / 1 N HCl / tetrahydrofuran / 48 h / 25 °C

6: 1.) PPh₃ / 1.) CH₂Cl₂, 0 deg C, 30 min, 2.) 25 deg C, 20 h

With hydrogenchloride; potassium hexamethylsilazane; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo00074a016