6-(2-(3-(but-3-ynyl)-3H-diazirin-3-yl)ethoxy)-N-(3-chloro-4-fluorophenyl)-7-methoxyquinazolin-4-amine

Base Information

Chemical Name:6-(2-(3-(but-3-ynyl)-3H-diazirin-3-yl)ethoxy)-N-(3-chloro-4-fluorophenyl)-7-methoxyquinazolin-4-amine
CAS No.:1450754-57-0
Molecular Formula:C₂₂H₁₉ClFN₅O₂
Molecular Weight:439.877
Hs Code.:

Synonyms:6-(2-(3-(but-3-ynyl)-3H-diazirin-3-yl)ethoxy)-N-(3-chloro-4-fluorophenyl)-7-methoxyquinazolin-4-amine

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Chemical Property of 6-(2-(3-(but-3-ynyl)-3H-diazirin-3-yl)ethoxy)-N-(3-chloro-4-fluorophenyl)-7-methoxyquinazolin-4-amine

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Technology Process of 6-(2-(3-(but-3-ynyl)-3H-diazirin-3-yl)ethoxy)-N-(3-chloro-4-fluorophenyl)-7-methoxyquinazolin-4-amine

There total 12 articles about 6-(2-(3-(but-3-ynyl)-3H-diazirin-3-yl)ethoxy)-N-(3-chloro-4-fluorophenyl)-7-methoxyquinazolin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1450754-38-7
3-(but-3-yn-1-yl)-3-(2-iodoethyl)-3H-diazirine

: 184475-71-6
4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline

: 1450754-57-0
6-(2-(3-(but-3-ynyl)-3H-diazirin-3-yl)ethoxy)-N-(3-chloro-4-fluorophenyl)-7-methoxyquinazolin-4-amine

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 12h; Inert atmosphere;
DOI:10.1002/anie.201300683

Reference yield:

: 230955-75-6
6-acetoxy-4-chloro-7-methoxyquinazoline

: 1450754-57-0
6-(2-(3-(but-3-ynyl)-3H-diazirin-3-yl)ethoxy)-N-(3-chloro-4-fluorophenyl)-7-methoxyquinazolin-4-amine

Guidance literature:: Multi-step reaction with 3 steps

1: isopropyl alcohol / Inert atmosphere

2: ammonium hydroxide / 3 h / Inert atmosphere; Reflux

3: potassium carbonate / N,N-dimethyl-formamide / 12 h / 60 °C / Inert atmosphere

With ammonium hydroxide; potassium carbonate; In N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1002/anie.201300683

Reference yield:

: 26759-46-6
methyl 2-amino-4,5-dimethoxybenzoate

: 1450754-57-0
6-(2-(3-(but-3-ynyl)-3H-diazirin-3-yl)ethoxy)-N-(3-chloro-4-fluorophenyl)-7-methoxyquinazolin-4-amine

Guidance literature:: Multi-step reaction with 7 steps

1: methanol; N,N-dimethyl-formamide / Inert atmosphere

2: methanesulfonic acid; DL-methionine / Inert atmosphere

3: pyridine / Inert atmosphere

4: thionyl chloride / N,N-dimethyl-formamide / Inert atmosphere

5: isopropyl alcohol / Inert atmosphere

6: ammonium hydroxide / 3 h / Inert atmosphere; Reflux

7: potassium carbonate / N,N-dimethyl-formamide / 12 h / 60 °C / Inert atmosphere

With ammonium hydroxide; thionyl chloride; methanesulfonic acid; potassium carbonate; DL-methionine; In pyridine; methanol; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1002/anie.201300683