5-chloro-6-{4-[4-(4-fluoro-phenyl)-6-trifluoromethyl-1H-benzoimidazol-2-yl]-3-methyl-piperazin-1-yl}-pyridin-3-ylamine

Base Information

Chemical Name:5-chloro-6-{4-[4-(4-fluoro-phenyl)-6-trifluoromethyl-1H-benzoimidazol-2-yl]-3-methyl-piperazin-1-yl}-pyridin-3-ylamine
CAS No.:900184-22-7
Molecular Formula:C₂₄H₂₁ClF₄N₆
Molecular Weight:504.918
Hs Code.:

5-chloro-6-{4-[4-(4-fluoro-phenyl)-6-trifluoromethyl-1<i>H</i>-benzoimidazol-2-yl]-3-methyl-piperazin-1-yl}-pyridin-3-ylamine

Synonyms:5-chloro-6-{4-[4-(4-fluoro-phenyl)-6-trifluoromethyl-1H-benzoimidazol-2-yl]-3-methyl-piperazin-1-yl}-pyridin-3-ylamine

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Chemical Property of 5-chloro-6-{4-[4-(4-fluoro-phenyl)-6-trifluoromethyl-1H-benzoimidazol-2-yl]-3-methyl-piperazin-1-yl}-pyridin-3-ylamine

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Technology Process of 5-chloro-6-{4-[4-(4-fluoro-phenyl)-6-trifluoromethyl-1H-benzoimidazol-2-yl]-3-methyl-piperazin-1-yl}-pyridin-3-ylamine

There total 8 articles about 5-chloro-6-{4-[4-(4-fluoro-phenyl)-6-trifluoromethyl-1H-benzoimidazol-2-yl]-3-methyl-piperazin-1-yl}-pyridin-3-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 900184-16-9
(R)-6-(4-(4-bromo-6-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)-3-methylpiperazin-1-yl)-5-chloropyridin-3-ylamine

: 1765-93-1
4-fluoroboronic acid

: 900184-22-7
5-chloro-6-{4-[4-(4-fluoro-phenyl)-6-trifluoromethyl-1H-benzoimidazol-2-yl]-3-methyl-piperazin-1-yl}-pyridin-3-ylamine

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In 1,2-dimethoxyethane; ethanol; water; at 82 ℃; for 3h;
DOI:10.1021/jm060065y

Reference yield:

: 75336-86-6
(2R)-methylpiperazine

: 900184-22-7
5-chloro-6-{4-[4-(4-fluoro-phenyl)-6-trifluoromethyl-1H-benzoimidazol-2-yl]-3-methyl-piperazin-1-yl}-pyridin-3-ylamine

Guidance literature:: Multi-step reaction with 4 steps

1: 99 percent / iPr₂NEt / 1-methyl-pyrrolidin-2-one / 1 h / 240 °C / microwave irradiation

2: 58 percent / iPr₂NEt; CuI / 3-methyl-butan-1-ol / 1 h / 200 °C / microwave irradiation

3: 44 percent / SnCl₂*2H₂O / dimethylformamide / 3 h / 80 °C

4: 66 percent / PdCl₂(PPh₃)2; Na₂CO₃ / 1,2-dimethoxy-ethane; ethanol; H₂O / 3 h / 82 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sodium carbonate; N-ethyl-N,N-diisopropylamine; tin(ll) chloride; In 1-methyl-pyrrolidin-2-one; 1,2-dimethoxyethane; ethanol; i-Amyl alcohol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm060065y

Reference yield:

: 683240-53-1
4-bromo-2-chloro-6-(trifluoromethyl)-1H-benzo[d]imidazole

: 900184-22-7
5-chloro-6-{4-[4-(4-fluoro-phenyl)-6-trifluoromethyl-1H-benzoimidazol-2-yl]-3-methyl-piperazin-1-yl}-pyridin-3-ylamine

Guidance literature:: Multi-step reaction with 3 steps

1: 58 percent / iPr₂NEt; CuI / 3-methyl-butan-1-ol / 1 h / 200 °C / microwave irradiation

2: 44 percent / SnCl₂*2H₂O / dimethylformamide / 3 h / 80 °C

3: 66 percent / PdCl₂(PPh₃)2; Na₂CO₃ / 1,2-dimethoxy-ethane; ethanol; H₂O / 3 h / 82 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sodium carbonate; N-ethyl-N,N-diisopropylamine; tin(ll) chloride; In 1,2-dimethoxyethane; ethanol; i-Amyl alcohol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm060065y