(R)-2-(5-chloro-6-(4-(4-(4-fluorophenyl)-6-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)-3-methylpiperazin-1-yl)pyridin-3-ylamino)-2-oxoethyl acetate

Base Information

Chemical Name:(R)-2-(5-chloro-6-(4-(4-(4-fluorophenyl)-6-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)-3-methylpiperazin-1-yl)pyridin-3-ylamino)-2-oxoethyl acetate
CAS No.:900184-24-9
Molecular Formula:C₂₈H₂₅ClF₄N₆O₃
Molecular Weight:604.992
Hs Code.:

Synonyms:(R)-2-(5-chloro-6-(4-(4-(4-fluorophenyl)-6-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)-3-methylpiperazin-1-yl)pyridin-3-ylamino)-2-oxoethyl acetate

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Chemical Property of (R)-2-(5-chloro-6-(4-(4-(4-fluorophenyl)-6-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)-3-methylpiperazin-1-yl)pyridin-3-ylamino)-2-oxoethyl acetate

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Technology Process of (R)-2-(5-chloro-6-(4-(4-(4-fluorophenyl)-6-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)-3-methylpiperazin-1-yl)pyridin-3-ylamino)-2-oxoethyl acetate

There total 9 articles about (R)-2-(5-chloro-6-(4-(4-(4-fluorophenyl)-6-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)-3-methylpiperazin-1-yl)pyridin-3-ylamino)-2-oxoethyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 900184-22-7
5-chloro-6-{4-[4-(4-fluoro-phenyl)-6-trifluoromethyl-1H-benzoimidazol-2-yl]-3-methyl-piperazin-1-yl}-pyridin-3-ylamine

: 13831-30-6
acetoxyacetic acid

: 900184-24-9
(R)-2-(5-chloro-6-(4-(4-(4-fluorophenyl)-6-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)-3-methylpiperazin-1-yl)pyridin-3-ylamino)-2-oxoethyl acetate

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 18h;
DOI:10.1021/jm060065y

Reference yield:

: 75336-86-6
(2R)-methylpiperazine

: 900184-24-9
(R)-2-(5-chloro-6-(4-(4-(4-fluorophenyl)-6-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)-3-methylpiperazin-1-yl)pyridin-3-ylamino)-2-oxoethyl acetate

Guidance literature:: Multi-step reaction with 5 steps

1: 99 percent / iPr₂NEt / 1-methyl-pyrrolidin-2-one / 1 h / 240 °C / microwave irradiation

2: 58 percent / iPr₂NEt; CuI / 3-methyl-butan-1-ol / 1 h / 200 °C / microwave irradiation

3: 44 percent / SnCl₂*2H₂O / dimethylformamide / 3 h / 80 °C

4: 66 percent / PdCl₂(PPh₃)2; Na₂CO₃ / 1,2-dimethoxy-ethane; ethanol; H₂O / 3 h / 82 °C

5: 99 percent / benzotriazol-1-yloxy-tris(dimethylamino)phosphonium PF₆; iPr₂NEt / CH₂Cl₂ / 18 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sodium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; tin(ll) chloride; In 1-methyl-pyrrolidin-2-one; 1,2-dimethoxyethane; ethanol; i-Amyl alcohol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm060065y

Reference yield:

: 683240-53-1
4-bromo-2-chloro-6-(trifluoromethyl)-1H-benzo[d]imidazole

: 900184-24-9
(R)-2-(5-chloro-6-(4-(4-(4-fluorophenyl)-6-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)-3-methylpiperazin-1-yl)pyridin-3-ylamino)-2-oxoethyl acetate

Guidance literature:: Multi-step reaction with 4 steps

1: 58 percent / iPr₂NEt; CuI / 3-methyl-butan-1-ol / 1 h / 200 °C / microwave irradiation

2: 44 percent / SnCl₂*2H₂O / dimethylformamide / 3 h / 80 °C

3: 66 percent / PdCl₂(PPh₃)2; Na₂CO₃ / 1,2-dimethoxy-ethane; ethanol; H₂O / 3 h / 82 °C

4: 99 percent / benzotriazol-1-yloxy-tris(dimethylamino)phosphonium PF₆; iPr₂NEt / CH₂Cl₂ / 18 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sodium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; tin(ll) chloride; In 1,2-dimethoxyethane; ethanol; i-Amyl alcohol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm060065y