(R)-2-Methylpiperazine

Base Information

• Chemical Name: (R)-2-Methylpiperazine
• CAS No.: 75336-86-6
• Molecular Formula: C5H12N2
• Molecular Weight: 100.164
• Hs Code.: 29335990
• European Community (EC) Number: 627-761-7
• UNII: P4XU643R8W
• DSSTox Substance ID: DTXSID30226296
• Nikkaji Number: J872.073H
• Mol file: 75336-86-6.mol

Synonyms:(R)-2-Methylpiperazine;(R)-(-)-2-Methylpiperazine;75336-86-6;(2R)-2-methylpiperazine;2-Methylpiperazine, (R)-;PIPERAZINE, 2-METHYL-, (2R)-;(R)-3-Methylpiperazine;(+)-2-Methylpiperazine;(R)-2-Methyl-Piperazine;r-(-)-2-methylpiperazine;R-(+)-2-Methylpiperazine;(R)-2-Methyl-1-piperazine;MFCD00192317;UNII-P4XU643R8W;P4XU643R8W;r-mp;(R)2-methylpiperazine;2(R)-methylpiperazine;2alpha-Methylpiperazine;(R)-2-methylpiperazin;2(R)-methyl piperazine;2-(R)-methylpiperazine;(R)-2-methyl piperazine;2-(R)-methyl piperazine;(2R)-2-methyl-piperazine;(2R)-2-methyl-piperizine;R-(+)-2-methylpiperizine;(R)-2-methy 1-piperazine;SCHEMBL17120;(R)(-)-2-methylpiperazine;(R)-(+)-2-methylpiperazine;(R)-(-)-2-methyl-piperazine;DTXSID30226296;JOMNTHCQHJPVAZ-RXMQYKEDSA-N;BCP19769;AKOS015840075;(R)-(-)-2-Methylpiperazine, 97%;AC-4396;AM81348;CS-W020739;DS-0786;PS-9320;BP-11286;HY-34767;A9603;M2091;EN300-60346;(R)-2-Methyl piperazine (L)tataric acid salt;A801965;Q27286182;(R)-2-METHYLPIPERAZINE

Chemical Property of (R)-2-Methylpiperazine

Chemical Property:

• Appearance/Colour: white to off-white crystals
• Melting Point: 91-93 °C(lit.)
• Refractive Index: 1.4378 (estimate)
• Boiling Point: 153.2 °C at 760 mmHg
• PKA: 9.31±0.40(Predicted)
• Flash Point: 45.1 °C
• PSA: 24.06000
• Density: 0.845 g/cm₃
• LogP: 0.22530
• Storage Temp.: Flammables area
• Sensitive.: Air Sensitive & Hygroscopic
• Water Solubility.: soluble
• XLogP3: -0.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 100.100048391
• Heavy Atom Count: 7
• Complexity: 54

Purity/Quality:

99% ^*data from raw suppliers

(R)-(-)-2-Methylpiperazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F,C,Xi
• Hazard Codes: F,C,Xi
• Statements: 11-36/37/38-34
• Safety Statements: 16-26-36/37/39-45-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1CNCCN1
• Isomeric SMILES: C[C@@H]1CNCCN1

Technology Process of (R)-2-Methylpiperazine

There total 16 articles about (R)-2-Methylpiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(R)-2-((R)-3-Methyl-piperazin-1-yl)-2-phenyl-ethanol (156022-78-5) → (2R)-methylpiperazine (75336-86-6)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol;

DOI:10.1016/S0040-4039(00)77163-2

Reference yield: 76.0%

(R)-3-Methyl-1-(phenylmethyl)piperazine (132871-11-5) → (2R)-methylpiperazine (75336-86-6)

Guidance literature:

With hydrogen; acetic acid; palladium on activated charcoal; In methanol; at 20 ℃; for 24h; under 760 Torr;

DOI:10.1081/SCC-200036590

Reference yield: 68.0%

(RS)-2-methylpiperazine (109-07-9) → (2R)-methylpiperazine (75336-86-6) + (S)-2-methylpiperazine (74879-18-8)

Guidance literature:

(RS)-2-methylpiperazine; With L-Tartaric acid; In water; acetic acid; at 85 ℃;

With calcium hydroxide; In water; at 80 ℃; for 5h; Reagent/catalyst; Solvent; Temperature;

upstream raw materials:

(1S,6S)-1,6-Bis-(2-chloro-phenyl)-1,6-diphenyl-hexa-2,4-diyne-1,6-diol; compound with (R)-2-methyl-piperazine

(R)-2-((R)-3-Methyl-piperazin-1-yl)-2-phenyl-ethanol

3-methyl-piperazine-2,5-dione

(R)-3-Methyl-1-(phenylmethyl)piperazine

Downstream raw materials:

5-Amino-1-cyclopropyl-6,8-difluoro-7-((R)-3-methyl-piperazin-1-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

(3R)-3-Methyl-1-Tritylpiperazine

1-benzoyl-3-(R)-methylpiperazine

(R)-1-(4-fluorobenzyl)-3-methylpiperazine