ethyl (R,S)-3-{[tert-butyl(diphenyl)silyl]oxy}-2-(hydroxymethyl)propanoate

Base Information

Chemical Name:ethyl (R,S)-3-{[tert-butyl(diphenyl)silyl]oxy}-2-(hydroxymethyl)propanoate
CAS No.:1394849-41-2
Molecular Formula:C₂₂H₃₀O₄Si
Molecular Weight:386.563
Hs Code.:

Synonyms:ethyl (R,S)-3-{[tert-butyl(diphenyl)silyl]oxy}-2-(hydroxymethyl)propanoate

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Chemical Property of ethyl (R,S)-3-{[tert-butyl(diphenyl)silyl]oxy}-2-(hydroxymethyl)propanoate

Chemical Property:

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Technology Process of ethyl (R,S)-3-{[tert-butyl(diphenyl)silyl]oxy}-2-(hydroxymethyl)propanoate

There total 4 articles about ethyl (R,S)-3-{[tert-butyl(diphenyl)silyl]oxy}-2-(hydroxymethyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 99116-11-7
3-Hydroxy-2-(hydroxymethyl)propionsaeure-ethylester

: 58479-61-1
tert-butylchlorodiphenylsilane

: 1394849-41-2
ethyl (R,S)-3-{[tert-butyl(diphenyl)silyl]oxy}-2-(hydroxymethyl)propanoate

Guidance literature:: With triethylamine; In acetonitrile; at -10 - 25 ℃; for 12h;
DOI:10.1021/op3001383

Reference yield:

: 20605-01-0
diethyl bis(hydroxymethyl)malonate

: 1394849-41-2
ethyl (R,S)-3-{[tert-butyl(diphenyl)silyl]oxy}-2-(hydroxymethyl)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1: toluene-4-sulfonic acid / water / 1 h / 25 °C

2: lithium chloride / water; dimethyl sulfoxide / 2 h / 160 °C

3: hydrogenchloride / methanol; water / 12 h / 25 °C

4: triethylamine / acetonitrile / 12 h / -10 - 25 °C

With hydrogenchloride; toluene-4-sulfonic acid; triethylamine; lithium chloride; In methanol; water; dimethyl sulfoxide; acetonitrile; 2: |Krapcho Dealkoxycarbonylation;
DOI:10.1021/op3001383

Reference yield:

: 51335-75-2
2,2-Dimethyl-1,3-dioxacyclohexane-5,5-dicarboxylic acid,diethyl ester

: 1394849-41-2
ethyl (R,S)-3-{[tert-butyl(diphenyl)silyl]oxy}-2-(hydroxymethyl)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: lithium chloride / water; dimethyl sulfoxide / 2 h / 160 °C

2: hydrogenchloride / methanol; water / 12 h / 25 °C

3: triethylamine / acetonitrile / 12 h / -10 - 25 °C

With hydrogenchloride; triethylamine; lithium chloride; In methanol; water; dimethyl sulfoxide; acetonitrile; 1: |Krapcho Dealkoxycarbonylation;
DOI:10.1021/op3001383