tert-butyl (R)-2-((tert-butoxycarbonyl)amino)-3-(4-(fluoromethoxy)phenyl)propanoate

Base Information

Chemical Name:tert-butyl (R)-2-((tert-butoxycarbonyl)amino)-3-(4-(fluoromethoxy)phenyl)propanoate
CAS No.:1417187-95-1
Molecular Formula:C₁₉H₂₈FNO₅
Molecular Weight:369.433
Hs Code.:

Synonyms:tert-butyl (R)-2-((tert-butoxycarbonyl)amino)-3-(4-(fluoromethoxy)phenyl)propanoate

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Chemical Property of tert-butyl (R)-2-((tert-butoxycarbonyl)amino)-3-(4-(fluoromethoxy)phenyl)propanoate

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Technology Process of tert-butyl (R)-2-((tert-butoxycarbonyl)amino)-3-(4-(fluoromethoxy)phenyl)propanoate

There total 4 articles about tert-butyl (R)-2-((tert-butoxycarbonyl)amino)-3-(4-(fluoromethoxy)phenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 373-52-4
bromofluoromethane

: 1414025-67-4
(R)-tert-butyl 2-(tert-butoxycarbonylamino) -3-(4-hydroxyphenyl)propanoate

: 1417187-95-1
tert-butyl (R)-2-((tert-butoxycarbonyl)amino)-3-(4-(fluoromethoxy)phenyl)propanoate

Guidance literature:: (R)-tert-butyl 2-(tert-butoxycarbonylamino) -3-(4-hydroxyphenyl)propanoate; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; for 0.5h;

bromofluoromethane; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 4h;

Reference yield: 21.0%

: 1414025-67-4
(R)-tert-butyl 2-(tert-butoxycarbonylamino) -3-(4-hydroxyphenyl)propanoate

: 114435-86-8
fluoromethyl 4-methylbenzenesulfonate

: 1417187-95-1
tert-butyl (R)-2-((tert-butoxycarbonyl)amino)-3-(4-(fluoromethoxy)phenyl)propanoate

Guidance literature:: With 18-crown-6 ether; ISOPROPYLAMIDE; caesium carbonate; at 80 ℃; for 1h;
DOI:10.1039/c9cc04901k

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1417187-95-1
tert-butyl (R)-2-((tert-butoxycarbonyl)amino)-3-(4-(fluoromethoxy)phenyl)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane; N,N-dimethyl-formamide / 2 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h

2.2: 4 h / 0 - 20 °C

With sodium hydride; triethylamine; In dichloromethane; N,N-dimethyl-formamide; mineral oil;