tert-butyl (6-(((benzyloxy)carbonyl)amino)-1-trityl-1H-pyrazolo[4,3-c]pyridin-3-yl)(ethyl)carbamate

Base Information

Chemical Name:tert-butyl (6-(((benzyloxy)carbonyl)amino)-1-trityl-1H-pyrazolo[4,3-c]pyridin-3-yl)(ethyl)carbamate
CAS No.:1589541-38-7
Molecular Formula:C₄₀H₃₉N₅O₄
Molecular Weight:653.781
Hs Code.:

Synonyms:tert-butyl (6-(((benzyloxy)carbonyl)amino)-1-trityl-1H-pyrazolo[4,3-c]pyridin-3-yl)(ethyl)carbamate

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Chemical Property of tert-butyl (6-(((benzyloxy)carbonyl)amino)-1-trityl-1H-pyrazolo[4,3-c]pyridin-3-yl)(ethyl)carbamate

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Technology Process of tert-butyl (6-(((benzyloxy)carbonyl)amino)-1-trityl-1H-pyrazolo[4,3-c]pyridin-3-yl)(ethyl)carbamate

There total 4 articles about tert-butyl (6-(((benzyloxy)carbonyl)amino)-1-trityl-1H-pyrazolo[4,3-c]pyridin-3-yl)(ethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.1%

: 621-84-1
O-benzyl carbamate

: 1589541-37-6
tert-butyl (6-chloro-1-trityl-1H-pyrazolo[4,3-c]pyridin-3-yl)(ethyl)carbamate

: 1589541-38-7
tert-butyl (6-(((benzyloxy)carbonyl)amino)-1-trityl-1H-pyrazolo[4,3-c]pyridin-3-yl)(ethyl)carbamate

Guidance literature:: With dicyclohexyl-(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine; [(2-di-cyclohexylphosphino-3,6-dimethoxy-2,4,6-triisopropyl-1,1-biphenyl)-2-(2-amino-1,1-biphenyl)]palladium(II) methanesulfonate; caesium carbonate; In 1,4-dioxane; at 100 ℃; for 16h; Reagent/catalyst; Time; Inert atmosphere; Sealed tube;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1589541-38-7
tert-butyl (6-(((benzyloxy)carbonyl)amino)-1-trityl-1H-pyrazolo[4,3-c]pyridin-3-yl)(ethyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere

1.2: 16 h / 20 °C

2.1: dicyclohexyl-(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine; caesium carbonate; [(2-di-cyclohexylphosphino-3,6-dimethoxy-2,4,6-triisopropyl-1,1-biphenyl)-2-(2-amino-1,1-biphenyl)]palladium(II) methanesulfonate / 1,4-dioxane / 16 h / 100 °C / Inert atmosphere; Sealed tube

With dicyclohexyl-(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine; [(2-di-cyclohexylphosphino-3,6-dimethoxy-2,4,6-triisopropyl-1,1-biphenyl)-2-(2-amino-1,1-biphenyl)]palladium(II) methanesulfonate; caesium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane;

Reference yield:

: 6-chloro-3-iodo-1-trityl-1H-pyrazolo[4,3-c]pyridine

: 1589541-38-7
tert-butyl (6-(((benzyloxy)carbonyl)amino)-1-trityl-1H-pyrazolo[4,3-c]pyridin-3-yl)(ethyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: rac-Pro-OH; copper(l) iodide; potassium carbonate / dimethyl sulfoxide / 24 h / 70 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere

2.2: 16 h / 20 °C

3.1: dicyclohexyl-(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine; caesium carbonate; [(2-di-cyclohexylphosphino-3,6-dimethoxy-2,4,6-triisopropyl-1,1-biphenyl)-2-(2-amino-1,1-biphenyl)]palladium(II) methanesulfonate / 1,4-dioxane / 16 h / 100 °C / Inert atmosphere; Sealed tube

With copper(l) iodide; dicyclohexyl-(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine; [(2-di-cyclohexylphosphino-3,6-dimethoxy-2,4,6-triisopropyl-1,1-biphenyl)-2-(2-amino-1,1-biphenyl)]palladium(II) methanesulfonate; potassium carbonate; caesium carbonate; rac-Pro-OH; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; dimethyl sulfoxide;