(S)-methyl 2-(3-(3-((tert-butoxycarbonyl)(ethyl)amino)-1-trityl-1H-pyrazolo[4,3-c]pyridin-6-yl)ureido)-2-phenylacetate

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Chemical Name:(S)-methyl 2-(3-(3-((tert-butoxycarbonyl)(ethyl)amino)-1-trityl-1H-pyrazolo[4,3-c]pyridin-6-yl)ureido)-2-phenylacetate
CAS No.:1589541-49-0
Molecular Formula:C₄₂H₄₂N₆O₅
Molecular Weight:710.833
Hs Code.:

Synonyms:(S)-methyl 2-(3-(3-((tert-butoxycarbonyl)(ethyl)amino)-1-trityl-1H-pyrazolo[4,3-c]pyridin-6-yl)ureido)-2-phenylacetate

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Chemical Property of (S)-methyl 2-(3-(3-((tert-butoxycarbonyl)(ethyl)amino)-1-trityl-1H-pyrazolo[4,3-c]pyridin-6-yl)ureido)-2-phenylacetate

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Technology Process of (S)-methyl 2-(3-(3-((tert-butoxycarbonyl)(ethyl)amino)-1-trityl-1H-pyrazolo[4,3-c]pyridin-6-yl)ureido)-2-phenylacetate

There total 6 articles about (S)-methyl 2-(3-(3-((tert-butoxycarbonyl)(ethyl)amino)-1-trityl-1H-pyrazolo[4,3-c]pyridin-6-yl)ureido)-2-phenylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1589541-39-8
tert-butyl (6-amino-1-trityl-1H-pyrazolo[4,3-c]pyridin-3-yl)(ethyl)carbamate

: 6591-61-3,24461-61-8,26682-99-5,37760-98-8
(S)-Phenylglycine methyl ester

: 530-62-1
1,1'-carbonyldiimidazole

: 1589541-49-0
(S)-methyl 2-(3-(3-((tert-butoxycarbonyl)(ethyl)amino)-1-trityl-1H-pyrazolo[4,3-c]pyridin-6-yl)ureido)-2-phenylacetate

Guidance literature:: tert-butyl (6-amino-1-trityl-1H-pyrazolo[4,3-c]pyridin-3-yl)(ethyl)carbamate; 1,1'-carbonyldiimidazole; With 1H-imidazole; In 1,4-dioxane; at 20 ℃; for 16h;

(S)-Phenylglycine methyl ester; With N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; for 14h;

Reference yield:

: 1589541-38-7
tert-butyl (6-(((benzyloxy)carbonyl)amino)-1-trityl-1H-pyrazolo[4,3-c]pyridin-3-yl)(ethyl)carbamate

: 1589541-49-0
(S)-methyl 2-(3-(3-((tert-butoxycarbonyl)(ethyl)amino)-1-trityl-1H-pyrazolo[4,3-c]pyridin-6-yl)ureido)-2-phenylacetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: palladium on activated charcoal; hydrogen / methanol; ethyl acetate / 16 h / 20 °C / Inert atmosphere

2.1: 1H-imidazole / 1,4-dioxane / 16 h / 20 °C

2.2: 14 h

With 1H-imidazole; palladium on activated charcoal; hydrogen; In 1,4-dioxane; methanol; ethyl acetate;

Reference yield:

: 1589541-37-6
tert-butyl (6-chloro-1-trityl-1H-pyrazolo[4,3-c]pyridin-3-yl)(ethyl)carbamate

: 1589541-49-0
(S)-methyl 2-(3-(3-((tert-butoxycarbonyl)(ethyl)amino)-1-trityl-1H-pyrazolo[4,3-c]pyridin-6-yl)ureido)-2-phenylacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: dicyclohexyl-(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine; caesium carbonate; [(2-di-cyclohexylphosphino-3,6-dimethoxy-2,4,6-triisopropyl-1,1-biphenyl)-2-(2-amino-1,1-biphenyl)]palladium(II) methanesulfonate / 1,4-dioxane / 16 h / 100 °C / Inert atmosphere; Sealed tube

2.1: palladium on activated charcoal; hydrogen / methanol; ethyl acetate / 16 h / 20 °C / Inert atmosphere

3.1: 1H-imidazole / 1,4-dioxane / 16 h / 20 °C

3.2: 14 h

With 1H-imidazole; dicyclohexyl-(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine; palladium on activated charcoal; [(2-di-cyclohexylphosphino-3,6-dimethoxy-2,4,6-triisopropyl-1,1-biphenyl)-2-(2-amino-1,1-biphenyl)]palladium(II) methanesulfonate; hydrogen; caesium carbonate; In 1,4-dioxane; methanol; ethyl acetate;