1-(3-ethylamino-1H-pyrazolo[4,3-c]pyridin-6-yl)-3-(S)-(2-hydroxy-2-methyl-1-phenylpropyl)urea

Base Information

Chemical Name:1-(3-ethylamino-1H-pyrazolo[4,3-c]pyridin-6-yl)-3-(S)-(2-hydroxy-2-methyl-1-phenylpropyl)urea
CAS No.:1589540-24-8
Molecular Formula:C₁₉H₂₄N₆O₂
Molecular Weight:368.439
Hs Code.:

Synonyms:1-(3-ethylamino-1H-pyrazolo[4,3-c]pyridin-6-yl)-3-(S)-(2-hydroxy-2-methyl-1-phenylpropyl)urea

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Chemical Property of 1-(3-ethylamino-1H-pyrazolo[4,3-c]pyridin-6-yl)-3-(S)-(2-hydroxy-2-methyl-1-phenylpropyl)urea

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Technology Process of 1-(3-ethylamino-1H-pyrazolo[4,3-c]pyridin-6-yl)-3-(S)-(2-hydroxy-2-methyl-1-phenylpropyl)urea

There total 7 articles about 1-(3-ethylamino-1H-pyrazolo[4,3-c]pyridin-6-yl)-3-(S)-(2-hydroxy-2-methyl-1-phenylpropyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: [3-(3-ethylamino-1H-pyrazolo[4,3-c]pyridin-6-yl)ureido]phenylacetic acid methyl ester trifluoroacetate salt

: 75-16-1
methylmagnesium bromide

: 1589540-24-8
1-(3-ethylamino-1H-pyrazolo[4,3-c]pyridin-6-yl)-3-(S)-(2-hydroxy-2-methyl-1-phenylpropyl)urea

Guidance literature:: In tetrahydrofuran; toluene; at 0 - 20 ℃; for 10h;

Reference yield:

: 1589541-38-7
tert-butyl (6-(((benzyloxy)carbonyl)amino)-1-trityl-1H-pyrazolo[4,3-c]pyridin-3-yl)(ethyl)carbamate

: 1589540-24-8
1-(3-ethylamino-1H-pyrazolo[4,3-c]pyridin-6-yl)-3-(S)-(2-hydroxy-2-methyl-1-phenylpropyl)urea

Guidance literature:: Multi-step reaction with 4 steps

1.1: palladium on activated charcoal; hydrogen / methanol; ethyl acetate / 16 h / 20 °C / Inert atmosphere

2.1: 1H-imidazole / 1,4-dioxane / 16 h / 20 °C

2.2: 14 h

3.1: triethylsilane / dichloromethane / 2 h / 20 °C

4.1: tetrahydrofuran; toluene / 10 h / 0 - 20 °C

With 1H-imidazole; triethylsilane; palladium on activated charcoal; hydrogen; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; ethyl acetate; toluene;

Reference yield:

: 1589541-37-6
tert-butyl (6-chloro-1-trityl-1H-pyrazolo[4,3-c]pyridin-3-yl)(ethyl)carbamate

: 1589540-24-8
1-(3-ethylamino-1H-pyrazolo[4,3-c]pyridin-6-yl)-3-(S)-(2-hydroxy-2-methyl-1-phenylpropyl)urea

Guidance literature:: Multi-step reaction with 5 steps

1.1: dicyclohexyl-(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine; caesium carbonate; [(2-di-cyclohexylphosphino-3,6-dimethoxy-2,4,6-triisopropyl-1,1-biphenyl)-2-(2-amino-1,1-biphenyl)]palladium(II) methanesulfonate / 1,4-dioxane / 16 h / 100 °C / Inert atmosphere; Sealed tube

2.1: palladium on activated charcoal; hydrogen / methanol; ethyl acetate / 16 h / 20 °C / Inert atmosphere

3.1: 1H-imidazole / 1,4-dioxane / 16 h / 20 °C

3.2: 14 h

4.1: triethylsilane / dichloromethane / 2 h / 20 °C

5.1: tetrahydrofuran; toluene / 10 h / 0 - 20 °C

With 1H-imidazole; triethylsilane; dicyclohexyl-(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine; palladium on activated charcoal; [(2-di-cyclohexylphosphino-3,6-dimethoxy-2,4,6-triisopropyl-1,1-biphenyl)-2-(2-amino-1,1-biphenyl)]palladium(II) methanesulfonate; hydrogen; caesium carbonate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; ethyl acetate; toluene;