3-(4-aminophenyl)-4-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-2H-chromen-2-one

Base Information

Chemical Name:3-(4-aminophenyl)-4-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-2H-chromen-2-one
CAS No.:1613152-67-2
Molecular Formula:C₂₇H₂₆N₂O₃
Molecular Weight:426.515
Hs Code.:

Synonyms:3-(4-aminophenyl)-4-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-2H-chromen-2-one

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Chemical Property of 3-(4-aminophenyl)-4-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-2H-chromen-2-one

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Technology Process of 3-(4-aminophenyl)-4-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-2H-chromen-2-one

There total 5 articles about 3-(4-aminophenyl)-4-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-2H-chromen-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1197-55-3
4-aminophenylacetic acid

: 1613152-67-2
3-(4-aminophenyl)-4-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-2H-chromen-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / Reflux

2: boron tribromide / dichloromethane / 1 h

3: potassium carbonate / acetone / Reflux

4: silver nitrate / tetrahydrofuran / 0.25 h / 125 °C / Microwave irradiation; Sealed tube

5: hydrogenchloride / water; ethanol / Reflux

With hydrogenchloride; boron tribromide; potassium carbonate; silver nitrate; In tetrahydrofuran; ethanol; dichloromethane; water; acetone; 1: |Perkin Coumarin Rearrangement;
DOI:10.1016/j.bmcl.2014.04.106

Reference yield:

: 18733-07-8
(2-hydroxyphenyl)(4-methoxyphenyl)methanone

: 1613152-67-2
3-(4-aminophenyl)-4-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-2H-chromen-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / Reflux

2: boron tribromide / dichloromethane / 1 h

3: potassium carbonate / acetone / Reflux

4: silver nitrate / tetrahydrofuran / 0.25 h / 125 °C / Microwave irradiation; Sealed tube

5: hydrogenchloride / water; ethanol / Reflux

With hydrogenchloride; boron tribromide; potassium carbonate; silver nitrate; In tetrahydrofuran; ethanol; dichloromethane; water; acetone; 1: |Perkin Coumarin Rearrangement;
DOI:10.1016/j.bmcl.2014.04.106

Reference yield:

: 1613152-62-7
N-(4-(4-(4-methoxyphenyl)-2-oxo-2H-chromen-3-yl)phenyl)acetamide

: 1613152-67-2
3-(4-aminophenyl)-4-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-2H-chromen-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: boron tribromide / dichloromethane / 1 h

2: potassium carbonate / acetone / Reflux

3: silver nitrate / tetrahydrofuran / 0.25 h / 125 °C / Microwave irradiation; Sealed tube

4: hydrogenchloride / water; ethanol / Reflux

With hydrogenchloride; boron tribromide; potassium carbonate; silver nitrate; In tetrahydrofuran; ethanol; dichloromethane; water; acetone;
DOI:10.1016/j.bmcl.2014.04.106