N-(4-(2-oxo-4-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-2H-chromen-3-yl)phenyl)acetamide

Base Information

• Chemical Name: N-(4-(2-oxo-4-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-2H-chromen-3-yl)phenyl)acetamide
• CAS No.: 1613152-65-0
• Molecular Formula: C₂₉H₂₈N₂O₄
• Molecular Weight: 468.552

Synonyms:N-(4-(2-oxo-4-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-2H-chromen-3-yl)phenyl)acetamide

Chemical Property of N-(4-(2-oxo-4-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-2H-chromen-3-yl)phenyl)acetamide

Chemical Property:

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Technology Process of N-(4-(2-oxo-4-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-2H-chromen-3-yl)phenyl)acetamide

There total 7 articles about N-(4-(2-oxo-4-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-2H-chromen-3-yl)phenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

malonic acid (141-82-2) + 3-(4-aminophenyl)-4-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-2H-chromen-2-one (1613152-67-2) → N-(4-(2-oxo-4-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-2H-chromen-3-yl)phenyl)acetamide (1613152-65-0)

Guidance literature:

malonic acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃;

3-(4-aminophenyl)-4-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-2H-chromen-2-one; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.bmcl.2014.04.106

Reference yield: 94.0%

pyrrolidine (123-75-1) + N-(4-(4-(4-(2-bromoethoxy)phenyl)-2-oxo-2H-chromen-3-yl)phenyl)acetamide (1613152-64-9) → N-(4-(2-oxo-4-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-2H-chromen-3-yl)phenyl)acetamide (1613152-65-0)

Guidance literature:

With silver nitrate; In tetrahydrofuran; at 125 ℃; for 0.25h; Microwave irradiation; Sealed tube;

DOI:10.1016/j.bmcl.2014.04.106

Reference yield: 58.0%

malonic acid (141-82-2) + 3-(4-aminophenyl)-4-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-2H-chromen-2-one (1613152-67-2) → N-(4-(2-oxo-4-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-2H-chromen-3-yl)phenyl)acetamide (1613152-65-0) + N1,N3-bis(4-(2-oxo-4-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-2H-chromen-3-yl)phenyl)malonamide (1613152-69-4)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.bmcl.2014.04.106

upstream raw materials:

4-aminophenylacetic acid

(2-hydroxyphenyl)(4-methoxyphenyl)methanone

pyrrolidine

N-(4-(4-(4-(2-bromoethoxy)phenyl)-2-oxo-2H-chromen-3-yl)phenyl)acetamide

Downstream raw materials:

C₆₀H₅₈N₄O₈

N¹,N¹⁰-bis(4-(2-oxo-4-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-2H-chromen-3-yl)phenyl)decanediamide

N¹,N³-bis(4-(2-oxo-4-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-2H-chromen-3-yl)phenyl)isophthalamide

N¹,N³-bis(4-(2-oxo-4-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-2H-chromen-3-yl)phenyl)malonamide

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