3-methyl-1H-pyrrole-2-carboxylic acid [(S)-1-[(6-amino-pyridin-3-ylmethyl)-carbamoyl]-2-(3,4-difluoro-phenyl)-ethyl]-amide trifluoroacetate

Base Information

Chemical Name:3-methyl-1H-pyrrole-2-carboxylic acid [(S)-1-[(6-amino-pyridin-3-ylmethyl)-carbamoyl]-2-(3,4-difluoro-phenyl)-ethyl]-amide trifluoroacetate
CAS No.:1194094-45-5
Molecular Formula:C₂HF₃O₂*C₂₁H₂₁F₂N₅O₂
Molecular Weight:527.451
Hs Code.:

Synonyms:3-methyl-1H-pyrrole-2-carboxylic acid [(S)-1-[(6-amino-pyridin-3-ylmethyl)-carbamoyl]-2-(3,4-difluoro-phenyl)-ethyl]-amide trifluoroacetate

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Chemical Property of 3-methyl-1H-pyrrole-2-carboxylic acid [(S)-1-[(6-amino-pyridin-3-ylmethyl)-carbamoyl]-2-(3,4-difluoro-phenyl)-ethyl]-amide trifluoroacetate

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Technology Process of 3-methyl-1H-pyrrole-2-carboxylic acid [(S)-1-[(6-amino-pyridin-3-ylmethyl)-carbamoyl]-2-(3,4-difluoro-phenyl)-ethyl]-amide trifluoroacetate

There total 6 articles about 3-methyl-1H-pyrrole-2-carboxylic acid [(S)-1-[(6-amino-pyridin-3-ylmethyl)-carbamoyl]-2-(3,4-difluoro-phenyl)-ethyl]-amide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 90724-57-5
3-methyl-1H-pyrrole-2-carboxylic acid

: (S)-2-amino-N-(6-amino-pyridin-3-ylmethyl)-3-(3,4-difluoro-phenyl)-propionamide dihydrochloride

: 76-05-1
trifluoroacetic acid

: 1194094-45-5
3-methyl-1H-pyrrole-2-carboxylic acid [(S)-1-[(6-amino-pyridin-3-ylmethyl)-carbamoyl]-2-(3,4-difluoro-phenyl)-ethyl]-amide trifluoroacetate

Guidance literature:: 3-methyl-1H-pyrrole-2-carboxylic acid; (S)-2-amino-N-(6-amino-pyridin-3-ylmethyl)-3-(3,4-difluoro-phenyl)-propionamide dihydrochloride; With benzotriazol-1-ol; In dichloromethane; at 0 ℃; for 0.25h; water soluble carbodiimide;

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 18h;

trifluoroacetic acid;

Reference yield:

: 4214-73-7
6-aminonicotinonitrile

: 1194094-45-5
3-methyl-1H-pyrrole-2-carboxylic acid [(S)-1-[(6-amino-pyridin-3-ylmethyl)-carbamoyl]-2-(3,4-difluoro-phenyl)-ethyl]-amide trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / palladium on activated charcoal / water / 18 h / 517.16 Torr

2.1: benzotriazol-1-ol; N,N-dimethyl-formamide / dichloromethane; water / 0.25 h / 0 °C / water soluble carbodiimide

2.2: 5 h / 0 - 20 °C

3.1: hydrogenchloride / 1,4-dioxane

4.1: benzotriazol-1-ol / dichloromethane / 0.25 h / 0 °C / water soluble carbodiimide

4.2: 18 h / 0 - 20 °C

With hydrogenchloride; benzotriazol-1-ol; N,N-dimethyl-formamide; palladium on activated charcoal; In 1,4-dioxane; dichloromethane; water;

Reference yield:

: 400720-77-6
tert-butyl N-[(6-aminopyridin-3-yl)methyl]carbamate

: 1194094-45-5
3-methyl-1H-pyrrole-2-carboxylic acid [(S)-1-[(6-amino-pyridin-3-ylmethyl)-carbamoyl]-2-(3,4-difluoro-phenyl)-ethyl]-amide trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

2.1: benzotriazol-1-ol; N,N-dimethyl-formamide / dichloromethane; water / 0.25 h / 0 °C / water soluble carbodiimide

2.2: 5 h / 0 - 20 °C

3.1: hydrogenchloride / 1,4-dioxane

4.1: benzotriazol-1-ol / dichloromethane / 0.25 h / 0 °C / water soluble carbodiimide

4.2: 18 h / 0 - 20 °C

With hydrogenchloride; benzotriazol-1-ol; N,N-dimethyl-formamide; In 1,4-dioxane; dichloromethane; water;