tert-butyl 4-(2-(((benzyloxy)carbonyl)amino)acetyl)piperazine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(2-(((benzyloxy)carbonyl)amino)acetyl)piperazine-1-carboxylate
CAS No.:353495-62-2
Molecular Formula:C₁₉H₂₇N₃O₅
Molecular Weight:377.44
Hs Code.:

Synonyms:tert-butyl 4-(2-(((benzyloxy)carbonyl)amino)acetyl)piperazine-1-carboxylate

Suppliers and Price of tert-butyl 4-(2-(((benzyloxy)carbonyl)amino)acetyl)piperazine-1-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl 4-(2-(((benzyloxy)carbonyl)amino)acetyl)piperazine-1-carboxylate

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of tert-butyl 4-(2-(((benzyloxy)carbonyl)amino)acetyl)piperazine-1-carboxylate

There total 5 articles about tert-butyl 4-(2-(((benzyloxy)carbonyl)amino)acetyl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1138-80-3
N-(Benzyloxycarbonyl)glycine

: 57260-71-6
1-t-Butoxycarbonylpiperazine

: 353495-62-2
tert-butyl 4-(2-(((benzyloxy)carbonyl)amino)acetyl)piperazine-1-carboxylate

Guidance literature:: With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 4h;
DOI:10.1002/jhet.2194

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 353495-62-2
tert-butyl 4-(2-(((benzyloxy)carbonyl)amino)acetyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / water; 1,4-dioxane / 25 h / 5 - 20 °C

2: palladium 10% on activated carbon; ammonium formate / methanol / 2 h / 65 °C / Reflux

3: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 4 h / 20 °C

With palladium 10% on activated carbon; ammonium formate; sodium hydrogencarbonate; triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;
DOI:10.1002/jhet.2194

Reference yield:

: 57260-70-5
4-benzyl-piperazine-1-carboxylic acid tert-butyl ester

: 353495-62-2
tert-butyl 4-(2-(((benzyloxy)carbonyl)amino)acetyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; ammonium formate / methanol / 2 h / 65 °C / Reflux

2: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 4 h / 20 °C

With palladium 10% on activated carbon; ammonium formate; triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In methanol; N,N-dimethyl-formamide;
DOI:10.1002/jhet.2194