2-{4-[3-(trifluoromethyl)phenyl]piperazinylbutyl}-4,7-endomethylene-1H-isoindole

Base Information

Chemical Name:2-{4-[3-(trifluoromethyl)phenyl]piperazinylbutyl}-4,7-endomethylene-1H-isoindole
CAS No.:1609464-87-0
Molecular Formula:C₂₄H₃₂F₃N₃
Molecular Weight:419.533
Hs Code.:

Synonyms:2-{4-[3-(trifluoromethyl)phenyl]piperazinylbutyl}-4,7-endomethylene-1H-isoindole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-{4-[3-(trifluoromethyl)phenyl]piperazinylbutyl}-4,7-endomethylene-1H-isoindole

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Technology Process of 2-{4-[3-(trifluoromethyl)phenyl]piperazinylbutyl}-4,7-endomethylene-1H-isoindole

There total 4 articles about 2-{4-[3-(trifluoromethyl)phenyl]piperazinylbutyl}-4,7-endomethylene-1H-isoindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1609464-82-5
N-({4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}butyl)bicyclo[2.2.1]hept-5-ene(2,3-endo)dicarboximide

: 1609464-87-0
2-{4-[3-(trifluoromethyl)phenyl]piperazinylbutyl}-4,7-endomethylene-1H-isoindole

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1080/00397911.2013.865236

Reference yield:

: 6265-30-1
(1R,2S,6R,7S)-4-azatricyclo[5.2.1.0(2,6)]dec-8-ene-3,5-dione

: 1609464-87-0
2-{4-[3-(trifluoromethyl)phenyl]piperazinylbutyl}-4,7-endomethylene-1H-isoindole

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / butanone / 24 h / Reflux

2: potassium carbonate / Reflux

3: lithium aluminium tetrahydride / diethyl ether / 0 - 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; potassium carbonate; In diethyl ether; butanone;
DOI:10.1080/00397911.2013.865236

Reference yield:

: 15532-75-9
1-(3-Trifluoromethylphenyl)piperazine

: 1609464-87-0
2-{4-[3-(trifluoromethyl)phenyl]piperazinylbutyl}-4,7-endomethylene-1H-isoindole

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / Reflux

2: lithium aluminium tetrahydride / diethyl ether / 0 - 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; potassium carbonate; In diethyl ether;
DOI:10.1080/00397911.2013.865236