L-Proline, 1-((4-chlorophenyl)methyl)-5-oxo-

Base Information

Chemical Name:L-Proline, 1-((4-chlorophenyl)methyl)-5-oxo-
CAS No.:59749-22-3
Molecular Formula:C₁₂H₁₂ClNO₃
Molecular Weight:253.685
Hs Code.:
DSSTox Substance ID:DTXSID40208467
Nikkaji Number:J356.495I
Wikidata:Q76150756
ChEMBL ID:CHEMBL1957590

Synonyms:1-((4-Chlorophenyl)methyl)-5-oxo-L-proline;59749-22-3;Acide N-(p-chlorobenzyl)pyroglutamique [French];L-Proline, 1-((4-chlorophenyl)methyl)-5-oxo-;CHEMBL1957590;Acide N-(p-chlorobenzyl)pyroglutamique;C12H12ClNO3;(S)-1-(4-Chlorobenzyl)-5-oxopyrrolidine-2-carboxylic acid;SCHEMBL16601331;DTXSID40208467;BDBM50366192;1-(4-Chlorobenzyl)-5-oxo-L-proline;LS-118912

Suppliers and Price of L-Proline, 1-((4-chlorophenyl)methyl)-5-oxo-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of L-Proline, 1-((4-chlorophenyl)methyl)-5-oxo-

Chemical Property:

Vapor Pressure:1.09E-10mmHg at 25°C
Boiling Point:496.9°Cat760mmHg
Flash Point:254.3°C
Density:1.418g/cm³
XLogP3:1.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:253.0505709
Heavy Atom Count:17
Complexity:313

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC(=O)N(C1C(=O)O)CC2=CC=C(C=C2)Cl
Isomeric SMILES:C1CC(=O)N([C@@H]1C(=O)O)CC2=CC=C(C=C2)Cl

Technology Process of L-Proline, 1-((4-chlorophenyl)methyl)-5-oxo-

There total 5 articles about L-Proline, 1-((4-chlorophenyl)methyl)-5-oxo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 59749-18-7
(S)-1-(4-Chloro-benzyl)-5-oxo-pyrrolidine-2-carboxylic acid methyl ester

: 116404-24-1,59749-22-3
(S)-1-(4-chlorobenzyl)-5-oxopyrrolidine-2-carboxylic acid

Guidance literature:: With sodium hydroxide; In water; for 24h; Yield given; Ambient temperature;

Reference yield:

: C₁₃H₁₃ClNO₃Pol

: 116404-24-1,59749-22-3
(S)-1-(4-chlorobenzyl)-5-oxopyrrolidine-2-carboxylic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 1.5h; solid phase reaction;
DOI:10.1016/j.bmc.2012.02.010

Reference yield:

: 98-79-3
L-Pyroglutamic acid

: 116404-24-1,59749-22-3
(S)-1-(4-chlorobenzyl)-5-oxopyrrolidine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: conc. H₂SO₄ / benzene / 20 h / Heating

2: 1.) NaH / 1.) benzene, a) room temp., b) 2 h, reflux; 2.) reflux, 24 h

3: 10percent aq. NaOH / H₂O / 24 h / Ambient temperature

With sodium hydroxide; sodium hydride; sulfuric acid; In water; benzene;