(2S)-2-(((perfluorophenoxy)(phenoxy)phosphoryl)amino)propionic acid ethyl ester

Base Information

• Chemical Name: (2S)-2-(((perfluorophenoxy)(phenoxy)phosphoryl)amino)propionic acid ethyl ester
• CAS No.: 1403250-94-1
• Molecular Formula: C₁₇H₁₅F₅NO₅P
• Molecular Weight: 439.276

Synonyms:(2S)-2-(((perfluorophenoxy)(phenoxy)phosphoryl)amino)propionic acid ethyl ester

Chemical Property of (2S)-2-(((perfluorophenoxy)(phenoxy)phosphoryl)amino)propionic acid ethyl ester

Chemical Property:

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Technology Process of (2S)-2-(((perfluorophenoxy)(phenoxy)phosphoryl)amino)propionic acid ethyl ester

There total 5 articles about (2S)-2-(((perfluorophenoxy)(phenoxy)phosphoryl)amino)propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2,3,4,5,6-pentafluorophenol (771-61-9) + (S)-alanine ethyl ester hydrochloride (1115-59-9) + O-phenyl phosphorodichloridate (770-12-7) → (2S)-2-(((perfluorophenoxy)(phenoxy)phosphoryl)amino)propionic acid ethyl ester (1403250-94-1)

Guidance literature:

(S)-alanine ethyl ester hydrochloride; O-phenyl phosphorodichloridate; With triethylamine; In dichloromethane; at -78 - 0 ℃; for 4.5h;

2,3,4,5,6-pentafluorophenol; With triethylamine; In dichloromethane; at 0 ℃; for 4.33h;

DOI:10.1021/acsmedchemlett.6b00270

Reference yield: 70.0%

2,3,4,5,6-pentafluorophenol (771-61-9) + (2S)-ethyl 2-(chloro(phenoxy)phosphorylamino)propanoate (245078-14-2) → (2S)-2-(((perfluorophenoxy)(phenoxy)phosphoryl)amino)propionic acid ethyl ester (1403250-94-1)

Guidance literature:

With triethylamine; In dichloromethane; for 4h; Cooling with ice;

Reference yield: 45.0%

→ (2S)-2-(((perfluorophenoxy)(phenoxy)phosphoryl)amino)propionic acid ethyl ester (1403250-94-1)

Guidance literature:

With triethylamine; In dichloromethane; at -5 - 20 ℃; for 20.33h; Inert atmosphere;

upstream raw materials:

2,3,4,5,6-pentafluorophenol

(S)-alanine ethyl ester hydrochloride

O-phenyl phosphorodichloridate

(2S)-ethyl 2-(chloro(phenoxy)phosphorylamino)propanoate

Downstream raw materials:

C₂₁H₂₇FN₃O₉P

(2S)-ethyl 2-(((((2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate

C₂₄H₃₂N₉O₈P

C₂₃H₃₂N₇O₈P

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