(trans)-N-((3-chloropyrazin-2-yl)methyl)-4-hydroxycyclohexanecarboxamide

Base Information

Chemical Name:(trans)-N-((3-chloropyrazin-2-yl)methyl)-4-hydroxycyclohexanecarboxamide
CAS No.:1326280-86-7
Molecular Formula:C₁₂H₁₆ClN₃O₂
Molecular Weight:269.731
Hs Code.:

Synonyms:(trans)-N-((3-chloropyrazin-2-yl)methyl)-4-hydroxycyclohexanecarboxamide

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Chemical Property of (trans)-N-((3-chloropyrazin-2-yl)methyl)-4-hydroxycyclohexanecarboxamide

Chemical Property:

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Technology Process of (trans)-N-((3-chloropyrazin-2-yl)methyl)-4-hydroxycyclohexanecarboxamide

There total 2 articles about (trans)-N-((3-chloropyrazin-2-yl)methyl)-4-hydroxycyclohexanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 939412-86-9,867165-53-5
C-(3-chloropyrazin-2-yl)-methylamine hydrochloride salt

: 3685-26-5
trans-4-hydroxycyclohexanecarboxylic acid

: 1326280-86-7
(trans)-N-((3-chloropyrazin-2-yl)methyl)-4-hydroxycyclohexanecarboxamide

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 16h;

Reference yield:

: 55557-52-3
2-chloro-3-cyanopyrazine

: 1326280-86-7
(trans)-N-((3-chloropyrazin-2-yl)methyl)-4-hydroxycyclohexanecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetic acid; hydrogen / water; acetonitrile / 4 h / 20 °C

1.2: 20 °C / Cooling with ice

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-7-aza-benzotriazole; triethylamine / dichloromethane / 20 °C

With 1-hydroxy-7-aza-benzotriazole; hydrogen; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; water; acetonitrile;