(2R,4S)-cis-4-(tert-butyl)-1,2-piperidinedicarboxylic acid 1-(phenylmethyl) ester

Base Information

Chemical Name:(2R,4S)-cis-4-(tert-butyl)-1,2-piperidinedicarboxylic acid 1-(phenylmethyl) ester
CAS No.:261777-35-9
Molecular Formula:C₁₈H₂₅NO₄
Molecular Weight:319.401
Hs Code.:

Synonyms:(2R,4S)-cis-4-(tert-butyl)-1,2-piperidinedicarboxylic acid 1-(phenylmethyl) ester

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Chemical Property of (2R,4S)-cis-4-(tert-butyl)-1,2-piperidinedicarboxylic acid 1-(phenylmethyl) ester

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Technology Process of (2R,4S)-cis-4-(tert-butyl)-1,2-piperidinedicarboxylic acid 1-(phenylmethyl) ester

There total 4 articles about (2R,4S)-cis-4-(tert-butyl)-1,2-piperidinedicarboxylic acid 1-(phenylmethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 23569-17-7
4-tert-butylpyridine N-oxide

: 261777-35-9
(2R,4S)-cis-4-(tert-butyl)-1,2-piperidinedicarboxylic acid 1-(phenylmethyl) ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: (CH₃)2NCOCl / CH₂Cl₂

2.1: aq. HCl / Heating

3.1: H₂ / PtO₂ / ethanol; H₂O

4.1: aq. NaOH

4.2: L-tyrosine hydrazide / methanol / Heating

With hydrogenchloride; sodium hydroxide; hydrogen; N,N-Dimethylcarbamoyl chloride; platinum(IV) oxide; In ethanol; dichloromethane; water; 1.1: cyanidation / 2.1: Hydrolysis / 3.1: Reduction / 4.1: Acylation / 4.2: rac. resolution;
DOI:10.1016/S0957-4166(99)00473-5

Reference yield:

: 42205-73-2
4-tert-butyl-2-cyanopyridine

: 261777-35-9
(2R,4S)-cis-4-(tert-butyl)-1,2-piperidinedicarboxylic acid 1-(phenylmethyl) ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: aq. HCl / Heating

2.1: H₂ / PtO₂ / ethanol; H₂O

3.1: aq. NaOH

3.2: L-tyrosine hydrazide / methanol / Heating

With hydrogenchloride; sodium hydroxide; hydrogen; platinum(IV) oxide; In ethanol; water; 1.1: Hydrolysis / 2.1: Reduction / 3.1: Acylation / 3.2: rac. resolution;
DOI:10.1016/S0957-4166(99)00473-5

Reference yield:

: 42205-74-3
4-tert-Butylpyridine-2-carboxylic acid

: 261777-35-9
(2R,4S)-cis-4-(tert-butyl)-1,2-piperidinedicarboxylic acid 1-(phenylmethyl) ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: H₂ / PtO₂ / ethanol; H₂O

2.1: aq. NaOH

2.2: L-tyrosine hydrazide / methanol / Heating

With sodium hydroxide; hydrogen; platinum(IV) oxide; In ethanol; water; 1.1: Reduction / 2.1: Acylation / 2.2: rac. resolution;
DOI:10.1016/S0957-4166(99)00473-5