42205-73-2

Usage

Uses

Used in Pharmaceutical Industry:
4-tert-Butylpyridine-2-carbonitrile is used as a key intermediate in the synthesis of pharmaceuticals for its unique structure and reactivity, enabling the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 4-tert-Butylpyridine-2-carbonitrile is utilized as an intermediate in the production of agrochemicals, contributing to the creation of innovative products for crop protection and enhancement of agricultural yields.
Used in Fine Chemicals Synthesis:
4-tert-Butylpyridine-2-carbonitrile serves as a versatile building block in the synthesis of fine chemicals, allowing for the development of specialty compounds used in various industries such as fragrances, dyes, and coatings.
It is crucial to handle 4-tert-Butylpyridine-2-carbonitrile with care due to its potential health and environmental hazards, ensuring proper safety measures are in place during its production, use, and disposal.

Upstream product

• 23569-17-7 4-tert-butylpyridine N-oxide 
• 7677-24-9 trimethylsilyl cyanide 
• 151-50-8 potassium cyanide 
• 95111-63-0 C₁₀H₁₆NO⁽¹⁺⁾*CH₃O₄S^(1-) 
• 77-78-1 dimethyl sulfate 
• 3978-81-2 4-tert-butylpyridine 

Downstream Products

• 41225-63-2 1-(4-tert-butylpyridin-2-yl)ethanone 
• 166897-61-6 N,N'-(4,5-dichloro-o-phenylene)bis(4-tert-butylpyridine-2-carboxamide) 
• 261777-35-9 (2R,4S)-cis-4-(tert-butyl)-1,2-piperidinedicarboxylic acid 1-(phenylmethyl) ester 
• 261777-40-6 (2R,4S)-cis-4-(tert-butyl)-1,2-piperidinedicarboxylic acid 2-methyl 1-(phenylmethyl) diester 
• 261777-43-9 (2S,4S)-trans-4-(tert-butyl)-1,2-piperidinedicarboxylic acid 2-methyl 1-(phenylmethyl) diester 
• 123811-75-6 4-tert-Butyl-pyridine-2-carboxylic acid; hydrochloride 
• 42205-74-3 4-tert-Butylpyridine-2-carboxylic acid 

Relevant academic research and scientific papers

(4-(([1,2,4]TRIAZOLO[4,3-A]PYRIDINE-6-YL)OXY)-1,2,3,4-TETRAHYDRONAPHTHALEN-1-YL) UREIDO DERIVATIVES AS ANTI-INFLAMMATORY P38 MAPK INHIBITORS FOR TREATING DISEASES OF THE RESPIRATORY TRACT

This invention relates to (4-(([l,2,4]triazolo[4,3-a]pyridine-6-yl) oxy)-1,2,3,4-tetrahydronaphthalen-1-yl)ureido derivatives that are p38 MAPK (mitogen activated protein kinase) inhibitors as antiinflammatory agents for treating diseases of the respirato

C?H Cyanation of 6-Ring N-Containing Heteroaromatics

Heteroaromatic nitriles are important compounds in drug discovery, both for their prevalence in the clinic and due to the diverse range of transformations they can undergo. As such, efficient and reliable methods to access them have the potential for far-reaching impact across synthetic chemistry and the biomedical sciences. Herein, we report an approach to heteroaromatic C?H cyanation through triflic anhydride activation, nucleophilic addition of cyanide, followed by elimination of trifluoromethanesulfinate to regenerate the cyanated heteroaromatic ring. This one-pot protocol is simple to perform, is applicable to a broad range of decorated 6-ring N-containing heterocycles, and has been shown to be suitable for late-stage functionalization of complex drug-like architectures.

Urea-functionalized M4L6 cage receptors: Anion-templated self-assembly and selective guest exchange in aqueous solutions

We present an extensive study of a novel class of de novo designed tetrahedral M4L6 (M = Ni, Zn) cage receptors, wherein internal decoration of the cage cavities with urea anion-binding groups, via functionalization of the organic components L, led to selective encapsulation of tetrahedral oxoanions EO4n- (E = S, Se, Cr, Mo, W, n = 2; E = P, n = 3) from aqueous solutions, based on shape, size, and charge recognition. External functionalization with tBu groups led to enhanced solubility of the cages in aqueous methanol solutions, thereby allowing for their thorough characterization by multinuclear (1H, 13C, 77Se) and diffusion NMR spectroscopies. Additional experimental characterization by electrospray ionization mass spectrometry, UV-vis spectroscopy, and single-crystal X-ray diffraction, as well as theoretical calculations, led to a detailed understanding of the cage structures, self-assembly, and anion encapsulation. We found that the cage self-assembly is templated by EO4n- oxoanions (n ≥ 2), and upon removal of the templating anion the tetrahedral M4L6 cages rearrange into different coordination assemblies. The exchange selectivity among EO4n- oxoanions has been investigated with 77Se NMR spectroscopy using 77SeO42- as an anionic probe, which found the following selectivity trend: PO 43- ? CrO42- > SO 42- > SeO42- > MoO 42- > WO42-. In addition to the complementarity and flexibility of the cage receptor, a combination of factors have been found to contribute to the observed anion selectivity, including the anions' charge, size, hydration, basicity, and hydrogen-bond acceptor abilities.

Methods of treatment of amyloidosis using bi-aryl aspartyl protease inhibitors

The invention relates to novel compounds and methods of treating diseases, disorders, and conditions associated with amyloidosis. Amyloidosis refers to a collection of diseases, disorders, and conditions associated with abnormal deposition of A-beta protein.

METHODS OF TREATMENT OF AMYLOIDOSIS USING ASPARTYL-PROTEASE INHIBITORS

The invention relates to acetyl 2-hydroxy-1,3-diaminospirocyclohexanes and derivatives thereof that are useful in treating diseases, disorders, and conditions associated with amyloidosis. Amyloidosis refers to a collection of diseases, disorders, and conditions associated with abnormal deposition of A-beta protein.

Synthesis of chiral nonracemic 4-trans-substituted pipecolic acid derivatives

The syntheses and resolutions of enantiomerically enriched 4-phenyl, 4- tert-butyl, and 4-isopropyl pipecolic acids are described. Optically active diastereomers were prepared by diastereomeric salt formation with the chiral base, L-tyrosine hydrazide, to

Synthesis, Crystal Structure and Catalytic Activities of

The compound H2bbpc , which has good solubility in organic solvents, has been prepared.Reaction of with H2bbpc in ethanol and in the presence of triethylamine gave , the crystal structure of which has been determined.This complex is an active catalyst for alkene epoxidation by PhIO, cyclopropanation of styrene by ethyl diazoacetate and aziridination of styrene by PhINO2SC6H4Me-p.Its cyclic voltammogram in dichloromethane showed a reversible Ru(III)-Ru(II) couple at -0.55 V and an oxidation couple at 0.32 V.

Antipruritic composition

An antipruritic composition for an oral medicine, injection, and external medicine, comprising an effective amount of a chelated zinc (e.g., zinc picolinate) as an antipruritic agent.

An Improved Synthesis of Homoproline and Derivatives

An improved, general synthesis of substituted homoprolines has been developed by using readily available substituted pyridines (1).A key step in this synthetic procedure involves the known conversion of pyridine-N-oxides to 2-cyanopyridines (3) in nearly quantitative yields.The resulting nitriles are hydrolyzed to the corresponding pyridine-2-carboxylic acids (4).Subsequent reduction of the aromatic ring with PtO2/H2 gives the homoprolines (5) in good yields as racemic cis isomers.This procedure also can be utilized for the preparation of 5,6-benzohomoprolines fromthe appropriate quinoline precursors.The N-tert-butyloxycarbonyl (Boc) derivatives of these amino acids (useful intermediates for peptide synthesis) were also prepared in good yields.