2-fluoro-4-[2-methyl-8-[(3-methylsulfonylphenyl)methylamino]imidazo[1,2-a]pyrazin-3-yl]phenol

Base Information

• Chemical Name: 2-fluoro-4-[2-methyl-8-[(3-methylsulfonylphenyl)methylamino]imidazo[1,2-a]pyrazin-3-yl]phenol
• CAS No.: 1436383-95-7
• Molecular Formula: C₂₁H₁₉FN₄O₃S
• Molecular Weight: 426.471
• Mol file: 1436383-95-7.mol

Synonyms:2-fluoro-4-[2-methyl-8-[(3-methylsulfonylphenyl)methylamino]imidazo[1,2-a]pyrazin-3-yl]phenol

Chemical Property of 2-fluoro-4-[2-methyl-8-[(3-methylsulfonylphenyl)methylamino]imidazo[1,2-a]pyrazin-3-yl]phenol

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

BF738735 ≥98%(HPLC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-fluoro-4-[2-methyl-8-[(3-methylsulfonylphenyl)methylamino]imidazo[1,2-a]pyrazin-3-yl]phenol

There total 3 articles about 2-fluoro-4-[2-methyl-8-[(3-methylsulfonylphenyl)methylamino]imidazo[1,2-a]pyrazin-3-yl]phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

(3-fluoro-4-hydroxy-phenyl)boronic acid (182344-14-5) + 3-bromo-2-methyl-N-[(3-methylsulfonylphenyl)methyl]imidazo[1,2-a]pyrazin-8-amine (1436383-97-9) → 2-fluoro-4-[2-methyl-8-[(3-methylsulfonylphenyl)methylamino]imidazo[1,2-a]pyrazin-3-yl]phenol (1436383-95-7)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate; In water; N,N-dimethyl-formamide; at 90 ℃; for 16h; Inert atmosphere; Sealed tube;

DOI:10.1021/ml400095m

Reference yield:

8-chloro-2-methyl-imidazo[1,2-a]pyrazine (85333-43-3) → 2-fluoro-4-[2-methyl-8-[(3-methylsulfonylphenyl)methylamino]imidazo[1,2-a]pyrazin-3-yl]phenol (1436383-95-7)

Guidance literature:

Multi-step reaction with 3 steps

1: N-Bromosuccinimide / dichloromethane / 2.5 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / 2-methyl-propan-1-ol / 16 h / 108 °C

3: caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; N,N-dimethyl-formamide / 16 h / 90 °C / Inert atmosphere; Sealed tube

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-Bromosuccinimide; caesium carbonate; N-ethyl-N,N-diisopropylamine; In dichloromethane; 2-methyl-propan-1-ol; water; N,N-dimethyl-formamide;

DOI:10.1021/ml400095m

Reference yield:

3-bromo-8-chloro-2-methyl-imidazo[1,2-a]pyrazine (1124321-36-3) → 2-fluoro-4-[2-methyl-8-[(3-methylsulfonylphenyl)methylamino]imidazo[1,2-a]pyrazin-3-yl]phenol (1436383-95-7)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / 2-methyl-propan-1-ol / 16 h / 108 °C

2: caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; N,N-dimethyl-formamide / 16 h / 90 °C / Inert atmosphere; Sealed tube

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate; N-ethyl-N,N-diisopropylamine; In 2-methyl-propan-1-ol; water; N,N-dimethyl-formamide;

DOI:10.1021/ml400095m

upstream raw materials:

8-chloro-2-methyl-imidazo[1,2-a]pyrazine

3-bromo-8-chloro-2-methyl-imidazo[1,2-a]pyrazine

(3-fluoro-4-hydroxy-phenyl)boronic acid

3-bromo-2-methyl-N-[(3-methylsulfonylphenyl)methyl]imidazo[1,2-a]pyrazin-8-amine