3-BroMo-8-chloro-2-MethyliMidazol[1,2-a]pyrazine

Base Information

• Chemical Name: 3-BroMo-8-chloro-2-MethyliMidazol[1,2-a]pyrazine
• CAS No.: 1124321-36-3
• Molecular Formula: C7H5BrClN3
• Molecular Weight: 246.494
• Mol file: 1124321-36-3.mol

Synonyms:3-BroMo-8-chloro-2-MethyliMidazol[1,2-a]pyrazine;3-bromo-8-chloro-2-methylimidazo[1,2-a]pyrazine

Chemical Property of 3-BroMo-8-chloro-2-MethyliMidazol[1,2-a]pyrazine

Chemical Property:

• PSA: 30.19000
• LogP: 2.45360

Purity/Quality:

97% ^*data from raw suppliers

3-Bromo-8-chloro-2-methylimidazo[1,2-a]pyrazine 97.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-BroMo-8-chloro-2-MethyliMidazol[1,2-a]pyrazine

There total 2 articles about 3-BroMo-8-chloro-2-MethyliMidazol[1,2-a]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

→ 3-bromo-8-chloro-2-methyl-imidazo[1,2-a]pyrazine (1124321-36-3)

Guidance literature:

Reference yield: 92.0%

8-chloro-2-methyl-imidazo[1,2-a]pyrazine (85333-43-3) → 3-bromo-8-chloro-2-methyl-imidazo[1,2-a]pyrazine (1124321-36-3)

Guidance literature:

With N-Bromosuccinimide; In dichloromethane; at 20 ℃; for 2.5h;

DOI:10.1021/ml400095m

Reference yield: 30.0%

3-bromo-8-chloro-2-methyl-imidazo[1,2-a]pyrazine (1124321-36-3) + mafenide hydrochloride (138-37-4) → 4-[(3-bromo-2-methyl-imidazo[1,2-a]pyrazin-8-ylamino)-methyl]-benzenesulphonamide (1124321-37-4)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In 2-methyl-propan-1-ol; at 108 ℃; for 16h;

upstream raw materials:

8-chloro-2-methyl-imidazo[1,2-a]pyrazine

Downstream raw materials:

4-[(3-bromo-2-methyl-imidazo[1,2-a]pyrazin-8-ylamino)-methyl]-benzenesulphonamide

4-[[[3-(4-hydroxyphenyl)-2-methyl-imidazo[1,2-a]pyrazin-8-yl]amino]methyl]benzenesulfonamide

4-[2-methyl-8-[(3-methylsulfonylphenyl)methylamino]imidazo[1,2-a]pyrazin-3-yl]phenol

2-fluoro-4-[2-methyl-8-[(3-methylsulfonylphenyl)methylamino]imidazo[1,2-a]pyrazin-3-yl]phenol

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