N-{4-[2-(4-Methoxy-benzyloxy)-ethoxymethyl]-phenyl}-2,2-dimethyl-propionamide

Base Information

• Chemical Name: N-{4-[2-(4-Methoxy-benzyloxy)-ethoxymethyl]-phenyl}-2,2-dimethyl-propionamide
• CAS No.: 137105-30-7
• Molecular Formula: C₂₂H₂₉NO₄
• Molecular Weight: 371.477
• Mol file: 137105-30-7.mol

Synonyms:N-{4-[2-(4-Methoxy-benzyloxy)-ethoxymethyl]-phenyl}-2,2-dimethyl-propionamide

Chemical Property of N-{4-[2-(4-Methoxy-benzyloxy)-ethoxymethyl]-phenyl}-2,2-dimethyl-propionamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-{4-[2-(4-Methoxy-benzyloxy)-ethoxymethyl]-phenyl}-2,2-dimethyl-propionamide

There total 5 articles about N-{4-[2-(4-Methoxy-benzyloxy)-ethoxymethyl]-phenyl}-2,2-dimethyl-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2-(4-methoxybenzyloxy)ethanol (13807-89-1) + 4-pivaloylaminobenzyl bromide (137105-37-4) → N-{4-[2-(4-Methoxy-benzyloxy)-ethoxymethyl]-phenyl}-2,2-dimethyl-propionamide (137105-30-7)

Guidance literature:

With barium dihydroxide; barium(II) oxide; In N,N-dimethyl-formamide; for 32h; Ambient temperature;

DOI:10.1016/0040-4039(91)80616-E

Reference yield: 58.0%

2-(4-methoxybenzyloxy)ethanol (13807-89-1) + 4-pivaloylaminobenzyl chloride (137105-36-3) → N-{4-[2-(4-Methoxy-benzyloxy)-ethoxymethyl]-phenyl}-2,2-dimethyl-propionamide (137105-30-7)

Guidance literature:

With barium dihydroxide; barium(II) oxide; In N,N-dimethyl-formamide; for 64h; Ambient temperature;

DOI:10.1016/0040-4039(91)80616-E

Reference yield:

4-aminobenzenemethanol (623-04-1) → N-{4-[2-(4-Methoxy-benzyloxy)-ethoxymethyl]-phenyl}-2,2-dimethyl-propionamide (137105-30-7)

Guidance literature:

Multi-step reaction with 3 steps

1: Et₃N / CH₂Cl₂ / 2.5 h / 0 °C

2: 93 percent / SOCl₂, DMF / CH₂Cl₂ / 0.5 h / Ambient temperature

3: 58 percent / Ba(OH)2*8H₂O - BaO / dimethylformamide / 64 h / Ambient temperature

With barium dihydroxide; thionyl chloride; triethylamine; N,N-dimethyl-formamide; barium(II) oxide; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/0040-4039(91)80616-E

upstream raw materials:

2-(4-methoxybenzyloxy)ethanol

4-pivaloylaminobenzyl chloride

4-pivaloylaminobenzyl bromide

4-aminobenzenemethanol