14-O-{[(1S,2S,4S)-4-amino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin

Base Information

Chemical Name:14-O-{[(1S,2S,4S)-4-amino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin
CAS No.:1061337-55-0
Molecular Formula:C₂₈H₄₅NO₅S
Molecular Weight:507.735
Hs Code.:

Synonyms:14-O-{[(1S,2S,4S)-4-amino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin

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Chemical Property of 14-O-{[(1S,2S,4S)-4-amino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin

Chemical Property:

Purity/Quality:

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Technology Process of 14-O-{[(1S,2S,4S)-4-amino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin

There total 12 articles about 14-O-{[(1S,2S,4S)-4-amino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1061660-17-0
14-O-{[(1RS,2RS,4RS)-4-tert-butoxycarbonylamino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin

: 1061337-51-6
14-O-{[(1R,2R,4R)-4-amino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin

: 1061337-55-0
14-O-{[(1S,2S,4S)-4-amino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin

Guidance literature:: 14-O-{[(1RS,2RS,4RS)-4-tert-butoxycarbonylamino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin; With phosphoric acid; In isopropyl alcohol; at 50 ℃; Industry scale;

With potassium carbonate; In dichloromethane; water; isopropyl alcohol; at 0 - 5 ℃; for 1h; Product distribution / selectivity; Industry scale;

Reference yield:

: pleuromutilin

: 1061337-51-6
14-O-{[(1R,2R,4R)-4-amino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin

: 1061337-55-0
14-O-{[(1S,2S,4S)-4-amino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / dichloromethane / 20.33 h / 10 - 25 °C / Reflux; Industry scale

2.1: sodium hydroxide / benzyltri(n-butyl)ammonium chloride / water; tert-butyl methyl ether / 1 h / 20 - 25 °C / Inert atmosphere

3.1: phosphoric acid / isopropyl alcohol / 50 °C / Industry scale

3.2: 1 h / 0 - 5 °C / Industry scale

With phosphoric acid; sodium hydroxide; benzyltri(n-butyl)ammonium chloride; In dichloromethane; tert-butyl methyl ether; water; isopropyl alcohol;

Reference yield:

: 31716-01-5
pleuromutilin tosylate

: 1061337-51-6
14-O-{[(1R,2R,4R)-4-amino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin

: 1061337-55-0
14-O-{[(1S,2S,4S)-4-amino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / benzyltri(n-butyl)ammonium chloride / water; tert-butyl methyl ether / 1 h / 20 - 25 °C / Inert atmosphere

2.1: phosphoric acid / isopropyl alcohol / 50 °C / Industry scale

2.2: 1 h / 0 - 5 °C / Industry scale

With phosphoric acid; sodium hydroxide; benzyltri(n-butyl)ammonium chloride; In tert-butyl methyl ether; water; isopropyl alcohol;