14-O-{[(1S,2S,4S)-4-amino-2-hydroxy-cyclohexyl-sulfanyl]-acetyl}-mutilin acetate

Base Information

Chemical Name:14-O-{[(1S,2S,4S)-4-amino-2-hydroxy-cyclohexyl-sulfanyl]-acetyl}-mutilin acetate
CAS No.:1352833-93-2
Molecular Formula:C₂H₄O₂*C₂₈H₄₅NO₅S
Molecular Weight:567.788
Hs Code.:

Synonyms:14-O-{[(1S,2S,4S)-4-amino-2-hydroxy-cyclohexyl-sulfanyl]-acetyl}-mutilin acetate

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Chemical Property of 14-O-{[(1S,2S,4S)-4-amino-2-hydroxy-cyclohexyl-sulfanyl]-acetyl}-mutilin acetate

Chemical Property:

Purity/Quality:

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Technology Process of 14-O-{[(1S,2S,4S)-4-amino-2-hydroxy-cyclohexyl-sulfanyl]-acetyl}-mutilin acetate

There total 8 articles about 14-O-{[(1S,2S,4S)-4-amino-2-hydroxy-cyclohexyl-sulfanyl]-acetyl}-mutilin acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1061337-55-0
14-O-{[(1S,2S,4S)-4-amino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin

: 64-19-7,77671-22-8
acetic acid

: 1352833-93-2
14-O-{[(1S,2S,4S)-4-amino-2-hydroxy-cyclohexyl-sulfanyl]-acetyl}-mutilin acetate

Guidance literature:: In Isopropyl acetate; at 20 - 25 ℃; for 2h;

Reference yield:

: 4771-80-6
1,2,5,6-tetrahydrobenzoic acid

: 1352833-93-2
14-O-{[(1S,2S,4S)-4-amino-2-hydroxy-cyclohexyl-sulfanyl]-acetyl}-mutilin acetate

Guidance literature:: Multi-step reaction with 10 steps

1.1: acetone / 3.33 h / 55 - 60 °C / Reflux

2.1: acetone / 0.25 h / Reflux; Resolution of racemate

3.1: hydrogenchloride / water; tert-butyl methyl ether / 0.25 h / 20 - 25 °C

4.1: triethylamine; diphenyl phosphoryl azide / toluene; tert-butyl alcohol / 0.25 h / 20 - 60 °C

4.2: 0.83 h / 50 °C

5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.5 h / 30 - 40 °C / Cooling with ice

6.1: toluene / 15 - 25 °C

6.2: 30 °C

6.3: 40 - 45 °C

7.1: hydrazine hydrate; diothiothreitol / dichloromethane / 0.42 h / 15 - 25 °C / Inert atmosphere

7.2: 0.48 h

8.1: sodium hydroxide / benzyltri(n-butyl)ammonium chloride / water; tert-butyl methyl ether / 0.08 h / 20 - 25 °C / Inert atmosphere

9.1: phosphoric acid / isopropyl alcohol / 35 - 50 °C

10.1: Isopropyl acetate / 2 h / 20 - 25 °C

With hydrogenchloride; phosphoric acid; diphenyl phosphoryl azide; hydrazine hydrate; triethylamine; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; diothiothreitol; benzyltri(n-butyl)ammonium chloride; In dichloromethane; tert-butyl methyl ether; Isopropyl acetate; water; isopropyl alcohol; acetone; toluene; tert-butyl alcohol; 4.1: Curtius Rearrangement;

Reference yield:

: 1350734-49-4
tert-butyl ((1S,3S,6R)-7-oxabicyclo[4.1.0]heptan-3-yl)carbamate

: 1352833-93-2
14-O-{[(1S,2S,4S)-4-amino-2-hydroxy-cyclohexyl-sulfanyl]-acetyl}-mutilin acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: toluene / 15 - 25 °C

1.2: 30 °C

1.3: 40 - 45 °C

2.1: hydrazine hydrate; diothiothreitol / dichloromethane / 0.42 h / 15 - 25 °C / Inert atmosphere

2.2: 0.48 h

3.1: sodium hydroxide / benzyltri(n-butyl)ammonium chloride / water; tert-butyl methyl ether / 0.08 h / 20 - 25 °C / Inert atmosphere

4.1: phosphoric acid / isopropyl alcohol / 35 - 50 °C

5.1: Isopropyl acetate / 2 h / 20 - 25 °C

With phosphoric acid; hydrazine hydrate; sodium hydroxide; diothiothreitol; benzyltri(n-butyl)ammonium chloride; In dichloromethane; tert-butyl methyl ether; Isopropyl acetate; water; isopropyl alcohol; toluene;